Longitudinal structural gray matter and white matter MRI changes in presymptomatic progranulin mutation carriers

Mutations in the progranulin (GRN) gene are a major source of inherited frontotemporal degeneration (FTD) spectrum disorders associated with TDP-43 proteinopathy. We use structural MRI to identify regions of baseline differences and longitudinal changes in gray matter (GM) and white matter (WM) in presymptomatic GRN mutation carriers (pGRN+) compared to young controls (yCTL). Cognitively intact first-degree relatives of symptomatic GRN+ FTD...