A Six-Year Prospective Study of the Prognosis and Predictors in Patients With Late-Life Depression

•The long-term prognosis of late-life depression is poor in terms of mortality and course. •Depression in later life is a chronic and disabling disorder, in which treatment is probably still suboptimal. •An unfavorable course is associated with a younger age at onset of depression, higher baseline depression, chronic pain, neuroticism and loneliness. •Patients with a partial remission might benefit from interventions targeting chronic diseases...