Match!

The UCP2 -866G/A, Ala55Val and UCP3 -55C/T polymorphisms are associated with premature coronary artery disease and cardiovascular risk factors in Mexican population

Published on May 21, 2018in Genetics and Molecular Biology2.127
· DOI :10.1590/1678-4685-gmb-2017-0008
Ricardo Gamboa15
Estimated H-index: 15
,
Claudia Huesca-Gómez8
Estimated H-index: 8
+ 7 AuthorsGilberto Vargas-Alarcón33
Estimated H-index: 33
Abstract
  • References (46)
  • Citations (0)
📖 Papers frequently viewed together
50 Citations
20192.67FEBS Letters
4 Authors (Jinran Li, ..., Yunfeng Zhao)
1 Citations
78% of Scinapse members use related papers. After signing in, all features are FREE.
References46
Newest
#1Leticia Brondani (UFRGS: Universidade Federal do Rio Grande do Sul)H-Index: 10
#2Taís Silveira Assmann (UFRGS: Universidade Federal do Rio Grande do Sul)H-Index: 11
Last. Daisy Crispim (UFRGS: Universidade Federal do Rio Grande do Sul)H-Index: 19
view all 6 authors...
Background The relationship between uncoupling protein (UCP) 1–3 polymorphisms and susceptibility to obesity has been investigated in several genetic studies. However, the impact of these polymorphisms on obesity is still under debate, with contradictory results being reported. Until this date, no meta-analysis evaluated the association of UCP polymorphisms with body mass index (BMI) variability. Thus, this paper describe a meta-analysis conducted to evaluate if the -3826A/G (UCP1); -866G/A, Ala...
39 CitationsSource
#1Luciana Gioli-Pereira (USP: University of São Paulo)H-Index: 5
#2Paulo Cjl Santos (USP: University of São Paulo)H-Index: 6
Last. Whady Hueb (USP: University of São Paulo)H-Index: 31
view all 7 authors...
Background UCP2 (uncoupling protein 2) plays an important role in cardiovascular diseases and recent studies have suggested that the A55V polymorphism can cause UCP2 dysfunction. The main aim was to investigate the association of A55V polymorphism with cardiovascular events in a group of 611 patients enrolled in the Medical, Angioplasty or Surgery Study II (MASS II), a randomized trial comparing treatments for patients with coronary artery disease and preserved left ventricular function.
8 CitationsSource
#1L.J. QinH-Index: 1
#2J. WenH-Index: 1
Last. Qingyang Huang (CCNU: Central China Normal University)H-Index: 4
view all 4 authors...
Uncoupling protein 2 (UCP2) is a mitochondrial transporter protein and can affect the function of β-cells. We investigated a possible association between functional UCP2 -866G/ A and Ala55Val polymorphisms and type 2 diabetes in 715 Hubei Han Chinese. No significant association was found, either for the -866G/A polymorphism (allele, P = 0.254; genotype, P = 0.508) or for the Ala55Val polymorphism (allele, P = 0.250; genotype, P = 0.896). Then, we reviewed the association of UCP2 -866G/A and Ala5...
2 CitationsSource
#1Joanna HoldysH-Index: 4
#2P. GronekH-Index: 6
Last. Daniel StanisławskiH-Index: 3
view all 4 authors...
Uncoupling proteins 2 and 3 (UCP2 and UCP3) as mitochondrial electron transporters are involved in regulation of ATP production and energy dissipation as heat. Energy efficiency plays an important role in physical per formance, especially in aerobic fitness. The aim of this study was to examine the association between maximal oxygen uptake and genetic variants of the UCP2 and UCP3 genes. The studies were carried out in a group of 154 men and 85 women, professional athletes representing various s...
9 CitationsSource
#1Bianca Marmontel de Souza (UFRGS: Universidade Federal do Rio Grande do Sul)H-Index: 12
#2Leticia Brondani (UFRGS: Universidade Federal do Rio Grande do Sul)H-Index: 10
Last. Daisy Crispim (UFRGS: Universidade Federal do Rio Grande do Sul)H-Index: 19
view all 8 authors...
Background Some studies have reported associations between five uncoupling protein (UCP) 1–3 polymorphisms and type 2 diabetes mellitus (T2DM). However, other studies have failed to confirm the associations. This paper describes a case-control study and a meta-analysis conducted to attempt to determine whether the following polymorphisms are associated with T2DM: -3826A/G (UCP1); -866G/A, Ala55Val and Ins/Del (UCP2) and -55C/T (UCP3). Methods The case-control study enrolled 981 T2DM patients and...
32 CitationsSource
Last. Alessandra CarnevaleH-Index: 19
view all 16 authors...
Background ABCA1 genetic variation is known to play a role in HDL-C levels and various studies have also implicated ABCA1 variation in cardiovascular risk. The functional ABCA1/R230C variant is frequent in the Mexican population and has been consistently associated with low HDL-C concentrations. Although it has been associated with other cardiovascular risk factors such as obesity and type 2 diabetes mellitus, it is not known whether it is associated with coronary artery disease (CAD). Aim The p...
39 CitationsSource
#1Leticia Brondani (UFRGS: Universidade Federal do Rio Grande do Sul)H-Index: 10
#2Taís Silveira Assmann (UFRGS: Universidade Federal do Rio Grande do Sul)H-Index: 11
Last. Daisy Crispim (UFRGS: Universidade Federal do Rio Grande do Sul)H-Index: 19
view all 6 authors...
1 SUMMARY It is well established that genetic factors play an important role in the development of both type 2 diabetes mellitus (DM2) and obesity, and that genetically susceptible subjects can develop these metabolic diseases after being exposed to environmental risk factors. Therefore, great efforts have been made to identify genes associated with DM2 and/or obesity. Uncoupling pro- tein 1 (UCP1) is mainly expressed in brown adipose tissue, and acts in thermogenesis, regula- tion of energy exp...
41 CitationsSource
#1Sukma Oktavianthi (Eijkman Institute for Molecular Biology)H-Index: 2
#2Hidayat Trimarsanto (Eijkman Institute for Molecular Biology)H-Index: 13
Last. Safarina G. Malik (Eijkman Institute for Molecular Biology)H-Index: 10
view all 9 authors...
Background: Uncoupling protein 2 (UCP2) gene polymorphisms have been reported as genetic risk factors for obesity and type 2 diabetes mellitus (T2DM). We examined the association of commonly observed UCP2 G(�866)A (rs659366) and Ala55Val (C>T) (rs660339) single nucleotide polymorphisms (SNPs) with obesity, high fasting plasma glucose, and serum lipids in a Balinese population. Methods: A total of 603 participants (278 urban and 325 rural subjects) were recruited from Bali Island, Indonesia. Fast...
31 CitationsSource
#1Kuanfeng Xu (Nanjing Medical University)H-Index: 9
#2Mei Zhang (Nanjing Medical University)H-Index: 8
Last. Tao Yang (Nanjing Medical University)H-Index: 15
view all 10 authors...
Aims/hypothesis A meta-analysis was performed to assess the association between the UCP2 −866G/A, UCP2 Ala55Val and UCP3 −55C/T polymorphisms and type 2 diabetes susceptibility.
22 CitationsSource
#1Bianca Marmontel de Souza (UFRGS: Universidade Federal do Rio Grande do Sul)H-Index: 12
Last. Daisy Crispim (UFRGS: Universidade Federal do Rio Grande do Sul)H-Index: 19
view all 6 authors...
Esta bem estabelecido que fatores geneticos tem papel importante no desenvolvimento do diabetes melito tipo 2 (DM2) bem como de suas complicacoes cronicas e que individuos geneticamente suscetiveis podem desenvolver essa doenca apos exposicao a fatores de risco ambientais. Assim, grandes esforcos tem sido feitos para a identificacao de genes associados ao DM2. A proteina desacopladora 2 (UCP2) e expressa em diversos tecidos e atua na protecao contra o estresse oxidativo, na regulacao negativa da...
49 CitationsSource
Cited By0
Newest