Prominent microglial activation in cortical white matter is selectively associated with cortical atrophy in primary progressive aphasia

Aims Primary progressive aphasia ( PPA ) is a clinical syndrome characterized by selective language impairments associated with focal cortical atrophy favouring the language dominant hemisphere. PPA is associated with Alzheimer's disease ( AD ), frontotemporal lobar degeneration ( FTLD ) and significant accumulation of activated microglia. Activated microglia can initiate an inflammatory cascade that may contribute to neurodegeneration, but...