Conformational dynamics in crystals reveal the molecular bases for D76N beta-2 microglobulin aggregation propensity
Abstract
Spontaneous aggregation of folded and soluble native proteins in vivo is still a poorly understood process. A prototypic example is the D76N mutant of beta-2 microglobulin (β2m) that displays an aggressive aggregation propensity. Here we investigate the dynamics of β2m by X-ray crystallography, solid-state NMR, and molecular dynamics simulations to unveil the effects of the D76N mutation. Taken together, our data highlight the presence of minor...
Paper Details
Title
Conformational dynamics in crystals reveal the molecular bases for D76N beta-2 microglobulin aggregation propensity
Published Date
Apr 25, 2018
Journal
Volume
9
Issue
1
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