Multiple RPAs make WRN syndrome protein a superhelicase
Abstract
RPA is known to stimulate the helicase activity of Werner syndrome protein (WRN), but the exact stimulation mechanism is not understood. We use single-molecule FRET and magnetic tweezers to investigate the helicase activity of WRN and its stimulation by RPA. We show that WRN alone is a weak helicase which repetitively unwind just a few tens of base pairs, but that binding of multiple RPAs to the enzyme converts WRN into a superhelicase that...
Paper Details
Title
Multiple RPAs make WRN syndrome protein a superhelicase
Published Date
Apr 14, 2018
Journal
Volume
46
Issue
9
Pages
4689 - 4698
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