Transmission genetics of drug-resistant hepatitis C virus
Abstract
Antiviral development is plagued by drug resistance and genetic barriers to resistance are needed. For HIV and hepatitis C virus (HCV), combination therapy has proved life-saving. The targets of direct-acting antivirals for HCV infection are NS3/4A protease, NS5A phosphoprotein and NS5B polymerase. Differential visualization of drug-resistant and -susceptible RNA genomes within cells revealed that resistant variants of NS3/4A protease and NS5A...
Paper Details
Title
Transmission genetics of drug-resistant hepatitis C virus
Published Date
Mar 28, 2018
Journal
Volume
7
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History