Original paper
HDAC11 suppresses the thermogenic program of adipose tissue via BRD2
Abstract
Little is known about the biological function of histone deacetylase 11 (HDAC11), which is the lone class IV HDAC. Here, we demonstrate that deletion of HDAC11 in mice stimulates brown adipose tissue (BAT) formation and beiging of white adipose tissue (WAT). Consequently, HDAC11-deficient mice exhibit enhanced thermogenic potential and, in response to high-fat feeding, attenuated obesity, improved insulin sensitivity, and reduced hepatic...
Paper Details
Title
HDAC11 suppresses the thermogenic program of adipose tissue via BRD2
Published Date
Aug 9, 2018
Journal
Volume
3
Issue
15
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Notes
History