The characteristics of ctDNA reveal the high complexity in matching the corresponding tumor tissues

Next-generation sequencing (NGS) is an efficient and sensitive method to detect mutations from ctDNA. Many features and clinical conditions could significantly affect the concordance between ctDNA and corresponding tumor tissues. Our goal was to systematically investigate the critical factors contributing to different concordance between ctDNA and corresponding tumor tissues.We recruited two groups of IIIB or IV lung cancer patients: The...