Original paper
Base editing with a Cpf1–cytidine deaminase fusion
Abstract
The targeting range of CRISPR-Cas9 base editors (BEs) is limited by their G/C-rich protospacer-adjacent motif (PAM) sequences. To overcome this limitation, we developed a CRISPR-Cpf1-based BE by fusing the rat cytosine deaminase APOBEC1 to a catalytically inactive version of Lachnospiraceae bacterium Cpf1. The base editor recognizes a T-rich PAM sequence and catalyzes C-to-T conversion in human cells, while inducing low levels of indels,...
Paper Details
Title
Base editing with a Cpf1–cytidine deaminase fusion
Published Date
Mar 19, 2018
Journal
Volume
36
Issue
4
Pages
324 - 327
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Notes
History