Glycogen synthase kinase 3β promotes liver innate immune activation by restraining AMP-activated protein kinase activation

Glycogen synthase kinase 3β (Gsk3β [Gsk3b]) is a ubiquitously expressed kinase with distinctive functions in different types of cells. Although its roles in regulating innate immune activation and ischaemia and reperfusion injuries (IRIs) have been well documented, the underlying mechanisms remain ambiguous, in part because of the lack of cell-specific tools in vivo.We created a myeloid-specific Gsk3b knockout (KO) strain to study the function...