The Origins and Vulnerabilities of Two Transmissible Cancers in Tasmanian Devils
Abstract
Transmissible cancers are clonal lineages that spread through populations via contagious cancer cells. Although rare in nature, two facial tumor clones affect Tasmanian devils. Here we perform comparative genetic and functional characterization of these lineages. The two cancers have similar patterns of mutation and show no evidence of exposure to exogenous mutagens or viruses. Genes encoding PDGF receptors have copy number gains and are present...
Paper Details
Title
The Origins and Vulnerabilities of Two Transmissible Cancers in Tasmanian Devils
Published Date
Apr 1, 2018
Journal
Volume
33
Issue
4
Pages
607 - 619.e15
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