Original paper
Increased Levels of Rictor Prevent Mutant Huntingtin-Induced Neuronal Degeneration
Abstract
Rictor associates with mTOR to form the mTORC2 complex, which activity regulates neuronal function and survival. Neurodegenerative diseases are characterized by the presence of neuronal dysfunction and cell death in specific brain regions such as for example Huntington’s disease (HD), which is characterized by the loss of striatal projection neurons leading to motor dysfunction. Although HD is caused by the expression of mutant huntingtin, cell...
Paper Details
Title
Increased Levels of Rictor Prevent Mutant Huntingtin-Induced Neuronal Degeneration
Published Date
Feb 19, 2018
Journal
Volume
55
Issue
10
Pages
7728 - 7742
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Notes
History