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Molecular Neurobiology
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4.59
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Papers 4393
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#1Michael Maes (Chula: Chulalongkorn University)H-Index: 70
#2Sunee Sirivichayakul (Chula: Chulalongkorn University)H-Index: 24
Last.Michel GeffardH-Index: 47
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Accumulating evidence suggests that TNF-α-mediated immune-neurotoxicity contributes to cognitive impairments and the overall severity of schizophrenia (OSOS). There are no data whether peripheral IL-6 and IL-4 may affect the phenome of schizophrenia above and beyond the effects of TNF-α and whether those cytokines are regulated by lowered natural IgM to malondialdehyde (MDA) and paraoxonase 1 enzyme activity. We assessed the aforementioned biomarkers in a cross-sectional study that enrolled schi...
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#1Ifeanyi Iwuchukwu (LSU: Louisiana State University)H-Index: 5
#2Doan Nguyen (Ochsner Medical Center)H-Index: 1
Last.Nicolas G. Bazan (LSU: Louisiana State University)H-Index: 82
view all 10 authors...
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#1Geir BjørklundH-Index: 19
#2Nagwa A. MeguidH-Index: 11
Last.Rene Kizek (VFU: University of Veterinary and Pharmaceutical Sciences Brno)H-Index: 51
view all 17 authors...
According to the United States Centers for Disease Control and Prevention (CDC), as of July 11, 2016, the reported average incidence of children diagnosed with an autism spectrum disorder (ASD) was 1 in 68 (1.46%) among 8-year-old children born in 2004 and living within the 11 monitoring sites’ surveillance areas in the United States of America (USA) in 2012. ASD is a multifaceted neurodevelopmental disorder that is also considered a hidden disability, as, for the most part; there are no apparen...
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#1Silvia Gasparini (Sapienza University of Rome)
#2Giorgia Del Vecchio (Sapienza University of Rome)H-Index: 2
Last.Arianna Rinaldi (Sapienza University of Rome)H-Index: 9
view all 12 authors...
Autism spectrum disorder (ASD) is a heterogeneous neurodevelopmental condition with unknown etiology. Recent experimental evidences suggest the contribution of non-coding RNAs (ncRNAs) in the pathophysiology of ASD. In this work, we aimed to investigate the expression profile of the ncRNA class of circular RNAs (circRNAs) in the hippocampus of the BTBR T + tf/J (BTBR) mouse model and age-matched C57BL/6J (B6) mice. Alongside, we analyzed BTBR hippocampal gene expression profile to evaluate possi...
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#1Dmitry Velmeshev (UM: University of Miami)H-Index: 10
#2Marco Magistri (UM: University of Miami)H-Index: 12
Last.Mohammad Ali Faghihi (UM: University of Miami)H-Index: 24
view all 8 authors...
Despite its heterogeneity, autism is characterized by a defined behavioral phenotype, suggesting that the molecular pathology affects specific neural substrates to cause behavioral dysfunction. Previous studies identified genes dysregulated in autism cortex but did not address their cell-type specificity. Moreover, it is unknown whether there is a core of genes dysregulated across multiple neocortical regions. We applied RNA sequencing to postmortem brain tissue samples from autism patients and ...
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#1Jiang WuH-Index: 3
#2Bihua BieH-Index: 9
Last.Mohamed NaguibH-Index: 37
view all 4 authors...
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#1Yasuhiro YamamotoH-Index: 30
#2Hiromi KomaH-Index: 5
Last.Tatsurou YagamiH-Index: 24
view all 3 authors...
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#1Manuela LoiH-Index: 2
#2Stefania TrazziH-Index: 17
Last.Elisabetta CianiH-Index: 33
view all 8 authors...
Mutations in the CDKL5 gene, which encodes a serine/threonine kinase, causes a rare encephalopathy, characterized by early-onset epilepsy and severe intellectual disability, named CDKL5 deficiency disorder (CDD). In vitro and in vivo studies in mouse models of Cdkl5 deficiency have highlighted the role of CDKL5 in brain development and, in particular, in the morphogenesis and synaptic connectivity of hippocampal and cortical neurons. Interestingly, Cdkl5 deficiency in mice increases vulnerabilit...
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#1Nirav PatelH-Index: 4
#2Kirk HoganH-Index: 28
Last.Solomon OndomaH-Index: 2
view all 20 authors...
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#1Olga Zolochevska (UTMB: University of Texas Medical Branch)H-Index: 10
#2Giulio Taglialatela (UTMB: University of Texas Medical Branch)H-Index: 36
Alzheimer’s disease (AD) is marked by synaptic loss (at early stages) and neuronal death (at late stages). Amyloid beta (Aβ) and tau oligomers can target and disrupt synapses thus driving cognitive decay. Non-demented individuals with Alzheimer’s neuropathology (NDAN) are capable of withstanding Aβ and tau toxicity, thus remaining cognitively intact despite presence of AD neuropathology. Understanding the involved mechanism(s) would lead to development of novel effective therapeutic strategies a...
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