Cryo-EM structure of human mTOR complex 2
Abstract
Mechanistic target of rapamycin (mTOR) complex 2 (mTORC2) plays an essential role in regulating cell proliferation through phosphorylating AGC protein kinase family members, including AKT, PKC and SGK1. The functional core complex consists of mTOR, mLST8, and two mTORC2-specific components, Rictor and mSin1. Here we investigated the intermolecular interactions within mTORC2 complex and determined its cryo-electron microscopy structure at 4.9 Å...
Paper Details
Title
Cryo-EM structure of human mTOR complex 2
Published Date
Mar 22, 2018
Journal
Volume
28
Issue
5
Pages
518 - 528
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