CRISPR /Cas9‐mediated MSTN disruption and heritable mutagenesis in goats causes increased body mass
Abstract
Genetic engineering in livestock has been greatly enhanced through the use of artificial programmed nucleases such as the recently emerged clustered regularly interspaced short palindromic repeats (CRISPR)/CRISPR-associated 9 (Cas9) system. We recently reported our successful application of the CRISPR/Cas9 system to engineer the goat genome through micro-injection of Cas9 mRNA and sgRNAs targeting MSTN and FGF5 in goat embryos. The phenotypes...
Paper Details
Title
Published Date
Feb 1, 2018
Journal
Volume
49
Issue
1
Pages
43 - 51
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