E2F1 promotes hepatic gluconeogenesis and contributes to hyperglycemia during diabetes
Abstract
Aberrant hepatic glucose production contributes to the development of hyperglycemia and is a hallmark of type 2 diabetes. In a recent study, we showed that the transcription factor E2F1, a component of the cell cycle machinery, contributes to hepatic steatosis through the transcriptional regulation of key lipogenic enzymes. Here, we investigate if E2F1 contributes to hyperglycemia by regulating hepatic gluconeogenesis. We use different genetic...
Paper Details
Title
E2F1 promotes hepatic gluconeogenesis and contributes to hyperglycemia during diabetes
Published Date
May 1, 2018
Journal
Volume
11
Pages
104 - 112
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