Match!

Cardiomyocyte-specific deletion of Sirt1 gene sensitizes myocardium to ischaemia and reperfusion injury

Published on May 1, 2018in Cardiovascular Research7.014
· DOI :10.1093/cvr/cvy033
Lin Wang6
Estimated H-index: 6
(UMMC: University of Mississippi Medical Center),
Nanhu Quan7
Estimated H-index: 7
(UMMC: University of Mississippi Medical Center)
+ 6 AuthorsJi Li34
Estimated H-index: 34
(UMMC: University of Mississippi Medical Center)
Abstract
  • References (67)
  • Citations (15)
📖 Papers frequently viewed together
4 Citations
2010
7 Authors (Matteo Becatti, ..., Paolo Nassi)
201423.05Circulation
6 Authors (Jinli Wang, ..., Ji Li)
78% of Scinapse members use related papers. After signing in, all features are FREE.
References67
Newest
#1Nanhu Quan (UMMC: University of Mississippi Medical Center)H-Index: 7
#2Wanqing Sun (UMMC: University of Mississippi Medical Center)H-Index: 5
Last. Ji Li (UMMC: University of Mississippi Medical Center)H-Index: 34
view all 10 authors...
A novel stress-inducible protein, Sestrin2 (Sesn2), declines in the heart with aging. AMPK has emerged as a pertinent stress-activated kinase that has been shown to have cardioprotective capabiliti...
24 CitationsSource
#1Wanqing Sun (UMMC: University of Mississippi Medical Center)H-Index: 5
#2Nanhu Quan (UMMC: University of Mississippi Medical Center)H-Index: 7
Last. Ji Li (UMMC: University of Mississippi Medical Center)H-Index: 34
view all 9 authors...
10 CitationsSource
#1Hui Yang (UMMC: University of Mississippi Medical Center)H-Index: 3
#2Wanqing Sun (UMMC: University of Mississippi Medical Center)H-Index: 5
Last. Ji Li (UMMC: University of Mississippi Medical Center)H-Index: 34
view all 9 authors...
AMP-activated protein kinase (AMPK) signaling pathway plays a pivotal role in intracellular adaptation to energy stress during myocardial ischemia. Notch1 signaling in the adult myocardium is also activated in response to ischemic stress. However, the relationship between Notch1 and AMPK signaling pathways during ischemia remains unclear. We hypothesize that Notch1 as an adaptive signaling pathway protects the heart from ischemic injury via modulating the cardioprotective AMPK signaling pathway....
19 CitationsSource
#1Stephan Winnik (UZH: University of Zurich)H-Index: 16
#2Johan Auwerx (EPFL: École Polytechnique Fédérale de Lausanne)H-Index: 137
Last. Christian M. Matter (UZH: University of Zurich)H-Index: 44
view all 4 authors...
Sirtuins (Sirt1–Sirt7) comprise a family of nicotinamide adenine dinucleotide (NAD+)-dependent enzymes. While deacetylation reflects their main task, some of them have deacylase, adenosine diphosphate-ribosylase, demalonylase, glutarylase, and desuccinylase properties. Activated upon caloric restriction and exercise, they control critical cellular processes in the nucleus, cytoplasm, and mitochondria to maintain metabolic homeostasis, reduce cellular damage and dampen inflammation—all of which s...
129 CitationsSource
#1Yina Ma (UB: University at Buffalo)H-Index: 3
#2Ji Li (UB: University at Buffalo)H-Index: 34
The heart is a very special organ in the body and has a high requirement for metabolism due to its constant workload. As a consequence, to provide a consistent and sufficient energy a high steady-state demand of metabolism is required by the heart. When delicately balanced mechanisms are changed by physiological or pathophysiological conditions, the whole system’s homeostasis will be altered to a new balance, which contributes to the pathologic process. So it is no wonder that almost every heart...
23 CitationsSource
#1Alex Morrison (UB: University at Buffalo)H-Index: 8
#2Li Chen (JLU: Jilin University)H-Index: 3
Last. Ji Li (UB: University at Buffalo)H-Index: 34
view all 10 authors...
The regulation of AMPK in the ischemic heart remains incompletely understood. Recent evidence implicates the role of Sestrin2 in the AMPK signaling pathway, and it is hypothesized that Sestrin2 plays an influential role during myocardial ischemia to promote AMPK activation. Sestrin2 protein was found to be expressed in adult cardiomyocytes and accumulated in the heart during ischemic conditions. Sestrin2 knockout (KO) mice were used to determine the importance of Sestrin2 during ischemia and rep...
59 CitationsSource
#1Xin-Yuan Luo (University of South China)H-Index: 2
#2Shun-Lin Qu (University of South China)H-Index: 5
Last. Zhi-Sheng Jiang (University of South China)H-Index: 17
view all 11 authors...
Abstract Cardiovascular disease (CVD) is the leading cause of death worldwide, with aging as the key independent risk factor. Effective interventions are necessary to delay aging. Sirtuin1 (SIRT1), a NAD + -dependent histone deacetylase, is closely related to lifespan extension. SIRT1 exerts beneficial effects on aging and age-related diseases, such as atherosclerosis. In this review, we summarize the current knowledge on the functions of SIRT1 in cardiovascular aging, focusing on the underlying...
27 CitationsSource
#1Yina MaH-Index: 2
#2Jinli WangH-Index: 5
Last. Alireza R. RezaieH-Index: 38
view all 8 authors...
Antithrombin (AT) is a protein of the serpin superfamily involved in regulation of the proteolytic activity of the serine proteases of the coagulation system. AT is known to exhibit anti-inflammatory and cardioprotective properties when it binds to heparan sulfate proteoglycans (HSPGs) on vascular cells. AMP-activated protein kinase (AMPK) plays an important cardioprotective role during myocardial ischaemia and reperfusion (I/R). To determine whether the cardioprotective signaling function of AT...
27 CitationsSource
#1Ling Liu (CQMU: Chongqing Medical University)H-Index: 2
#2Ping Wang (CQMU: Chongqing Medical University)H-Index: 2
Last. Ying Yu (CQMU: Chongqing Medical University)H-Index: 2
view all 6 authors...
Abstract Nicotinamide adenine dinucleotide (NAD(+) ) not only transfers electrons in mitochondrial respiration, but also acts as an indispensable cosubstrate for Sirt1, the class III histone/nonhistone deacetylase. However, NAD(+) is depleted in myocardial ischemia/reperfusion (IR) injury. The objective of this study was to investigate the role of exogenous NAD(+) supplementation in hypoxia/reoxygenation (HR)-stressed H9c2 cardiac myoblasts. Firstly, the effects of distinct treating time points ...
21 CitationsSource
#1Si Chen (SUNY: State University of New York System)H-Index: 1
#2Ping Zhu (Academy of Medical Sciences, United Kingdom)H-Index: 9
Last. Ji Li (SUNY: State University of New York System)H-Index: 34
view all 12 authors...
Aims The specific role of AMPKα1 or AMPKα2 in mediating cardiomyocyte contractile function remains elusive. The present study investigated how AMPK activation modulates the contractility of isolated cardiomyocytes.
19 CitationsSource
Cited By15
Newest
#1Yi Yang (WMU: Wenzhou Medical College)
#2Yinmeng Zhu (WMU: Wenzhou Medical College)
Last. Jianguang Wang (WMU: Wenzhou Medical College)
view all 11 authors...
Abstract Mitochondrial dysfunction is increasingly considered as the center of pathophysiology in sepsis-induced cardiac dysfunction. Maresin conjugates in tissue regeneration 1 (MCTR1) is a newly identified specialized pro-resolving mediator (SPM) and has been shown to accelerate tissue regeneration and exert positive inotropic effects. Our present study aims to investigate the effect of MCTR1 on lipopolysaccharide (LPS)-induced cardiac dysfunction and explore its potential mechanisms. Mice wer...
Source
#1Ying Han (USF: University of South Florida)
#2Weiju Sun (USF: University of South Florida)
Last. Ji Li (USF: University of South Florida)H-Index: 34
view all 9 authors...
Abstract Nucleotide-binding oligomerization domain-Like Receptor with a Pyrin domain 3 (NLRP3) inflammasome was emerged as a marker of metabolic dysregulation. We revealed that age-related Sirtuin-1 (SIRT1) modulates cardiac metabolism that medicated inflammatory response during ischemia and reperfusion (I/R) stress. We hypothesize that SIRT1 attenuates NLRP3 inflammasome-dependent inflammation and pyroptosis during myocardial I/R through metabolic modulation. C57BL/6J wild type (WT) mice, induc...
Source
#1Milton Packer (Imperial College London)H-Index: 7
#1Milton Packer (Baylor University Medical Center)H-Index: 76
Sodium-glucose cotransporter 2 (SGLT2) inhibitors reduce the risk of serious heart failure events, even though SGLT2 is not expressed in the myocardium. This cardioprotective benefit is not related to an effect of these drugs to lower blood glucose, promote ketone body utilization or enhance natriuresis, but it is linked statistically with their action to increase hematocrit. SGLT2 inhibitors increase both erythropoietin and erythropoiesis, but the increase in red blood cell mass does not direct...
Source
#1Refaat A. Eid (King Khalid University)H-Index: 12
Last. S.A. Al-Harbi (UQU: Umm al-Qura University)H-Index: 1
view all 12 authors...
This study evaluated if the cardioprotective effect of Exendin-4 against ischemia/reperfusion (I/R) injury in male rats involves modulation of AMPK and sirtuins. Adult male rats were divided into sham, sham + Exendin-4, I/R, I/R + Exendin-4, and I/R + Exendin-4 + EX-527, a sirt1 inhibitor. Exendin-4 reduced infarct size and preserved the function and structure of the left ventricles (LV) of I/R rats. It also inhibited oxidative stress and apoptosis and upregulated MnSOD and Bcl-2 in their infarc...
Source
#1Yan YanH-Index: 1
#2Huihuang YangH-Index: 1
Last. Haibing YuH-Index: 2
view all 6 authors...
Alzheimer's disease (AD), a common irreversible neurodegenerative disease characterized by amyloid-β plaques, neurofibrillary tangles, and changes in tau phosphorylation, is accompanied by memory loss and symptoms of cognitive dysfunction. Increases in disease incidence due to the ageing of the population have placed a great burden on society. To date, the mechanism of AD and the identities of adequate drugs for AD prevention and treatment have eluded the medical community. It has been confirmed...
1 CitationsSource
#1Zsolt Radak (Waseda University)H-Index: 51
#2Katsuhiko Suzuki (Waseda University)H-Index: 38
Last. Istvan Boldogh (UTMB: University of Texas Medical Branch)H-Index: 31
view all 6 authors...
Abstract Cellular energy demands are readily changed during physical exercise resulting in adaptive responses by signaling proteins of metabolic processes, including the NAD+ dependent lysine deacetylase SIRT1. Regular exercise results in systemic adaptation that restores the level of SIRT1 in the kidney, liver, and brain in patients with neurodegenerative diseases, and thereby normalizes cellular metabolic processes to attenuate the severity of these diseases. In skeletal muscle, over-expressio...
Source
#1Haobo Li (Harvard University)
#1Haobo Li (Harvard University)H-Index: 18
Last. Anthony Rosenzweig (Harvard University)H-Index: 69
view all 6 authors...
During aging, deterioration in cardiac structure and function leads to increased susceptibility to heart failure. The need for interventions to combat this age-related cardiac decline is becoming i...
Source
#1Yifei An (SDU: Shandong University)H-Index: 1
#2Bo Wang (SDU: Shandong University)H-Index: 13
Last. Qing Yang (KI: Karolinska Institutet)
view all 6 authors...
Chemotherapy is the standard care for patients with gastric cancer (GC); however, resistance to existing drugs has limited its success. The persistence of cancer stem cells (CSCs) is considered to be responsible for treatment failure. In this study, we demonstrated that SIRT1 expression was significantly downregulated in GC tissues, and that a low SIRT1 expression level indicated a poor prognosis in GC patients. We observed a suppressive role of SIRT1 in chemoresistance of GC both in vitro and i...
Source
In five large-scale trials involving >40 000 patients, sodium-glucose cotransporter 2 (SGLT2) inhibitors decreased the risk of serious heart failure events by 25-40%. This effect cannot be explained by control of hyperglycaemia, since it is not observed with antidiabetic drugs with greater glucose-lowering effects. It cannot be attributed to ketogenesis, since it is not causally linked to ketone body production, and the benefit is not enhanced in patients with diabetes. The effect cannot be ascr...
1 CitationsSource
#1Qingguo Lu (Sichuan University)H-Index: 3
#2Jia Liu (USF: University of South Florida)H-Index: 3
Last. Ji Li (USF: University of South Florida)H-Index: 34
view all 8 authors...
Abstract The beneficial effects of empagliflozin (EMPA) on cardiac functions during ischemia and reperfusion were characterized. The contractile functions of isolated cardiomyocytes from adult C57BL/6J mice were determined with IonOptix SoftEdgeMyoCam system. The mitochondrial superoxide production was measured by MitoSOX fluorescent probe. The ex vivo isolated heart perfusion system was used to determine the pharmacological effects of EMPA on heart's contractile functions under both physiologic...
3 CitationsSource