Disentangling the biological pathways involved in early features of Alzheimer's disease in the Rotterdam Study

Introduction Exploring the role of Alzheimer's disease (AD) implicated pathways in the predementia phase may provide new insight for preventive and clinical trials targeting disease specific pathways. Methods We constructed weighted Genetic risk scores, first based on 20 genome‐wide significant AD risk variants and second clustering these variants within pathways. Risk scores were investigated for their association with AD, mild cognitive...