3D QSAR Pharmacophore Based Virtual Screening for Identification of Potential Inhibitors for CDC25B

Owing to its fundamental roles in cell cycle phases, the cell division cycle 25B (CDC25B) was broadly considered as potent clinical drug target for cancers. In this study, 3D QSAR pharmacophore models for CDC25B inhibitors were developed by the module of Hypogen. Three methods (cost analysis, test set prediction, and Fisher’s test) were applied to validate that the models could be used to predict the biological activities of compounds....