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Computational Biology and Chemistry
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Papers 2901
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#1Nisar Wani (Jamia Millia Islamia)H-Index: 1
#2Khalid Raza (Jamia Millia Islamia)H-Index: 8
Abstract Data generation using high throughput technologies has led to the accumulation of diverse types of molecular data. These data have different types (discrete, real, string, etc.) and occur in various formats and sizes. Datasets including gene expression, miRNA expression, protein–DNA binding data (ChIP-Seq/ChIP-ChIP), mutation data (copy number variation, single nucleotide polymorphisms), annotations, interactions, and association data are some of the commonly used biological datasets to...
#1Azminah Azminah (University of Surabaya)H-Index: 1
#2Linda Erlina (UI: University of Indonesia)H-Index: 1
Last.Arry Yanuar (UI: University of Indonesia)H-Index: 4
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Abstract Sirtuin 1 (SIRT1) is a class III family of protein histone deacetylases involved in NAD+-dependent deacetylation reactions. It has been suggested that SIRT1 activators may have a protective role against type 2 diabetes, the aging process, and inflammation. This study aimed to explore and identify medicinal plant compounds from Indonesian Herbal Database (HerbalDB) that might potentially become a candidate for SIRT1 activators through a combination of in silico and in vitro methods. Two ...
#1Loo Keat Wei (UTAR: Universiti Tunku Abdul Rahman)
#2Leong Shi Quan (UTAR: Universiti Tunku Abdul Rahman)
Abstract According to the Trial of Org 10172 in Acute Stroke Treatment, ischemic stroke is classified into five subtypes. However, the predictive biomarkers of ischemic stroke subtypes are still largely unknown. The utmost objective of this study is to map, construct and analyze protein-protein interaction (PPI) networks for all subtypes of ischemic stroke, and to suggest the predominant biological pathways for each subtypes. Through 6285 protein data retrieved from PolySearch2 and STRING databa...
#1Basit Jabbar (University of the Punjab)H-Index: 3
#2Muhammad Shahzad Iqbal (UQ: University of Queensland)
Last.Robert J Henry (UQ: University of Queensland)H-Index: 62
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Abstract In order to maintain a consistent supply of rice globally, control of pathogens affecting crop production is a matter of due concern. Rice yellow mottle virus(RYMV) is known to cause a variety of symptoms which can result in reduced yield. Four ORFs can be identified in the genome of RYMV encoding for P1 (ORF1), Polyprotein (processed to produce VPg, protease, helicase, RdRp4) (ORF2), putative RdRp (ORF3) and capsid/coat protein (ORF4). This research was aimed at identifying genome enco...
#1Shuping Cheng (Beijing University of Technology)
#2Lu Zhang (Beijing University of Technology)
Last.Xiaoyi Zhang (Beijing University of Technology)H-Index: 7
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Abstract ncRNA-protein interactions (ncRPIs) play an important role in a number of cellular processes, such as post-transcriptional modification, transcriptional regulation, disease progression and development. Since experimental methods are expensive and time-consuming to identify the ncRPIs, we proposed a computational method, Deep Mining ncRNA-Protein Interactions (DM-RPIs), for identifying the ncRPIs. In order to descending dimension and excavating hidden information from k-mer frequency of ...
#1Mayank (IIT-RPR: Indian Institute of Technology Ropar)H-Index: 4
#2Ashutosh Singh (IIT Mandi: Indian Institute of Technology Mandi)H-Index: 5
Last.Narinder Singh (IIT-RPR: Indian Institute of Technology Ropar)H-Index: 33
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Abstract In this paper, we have established methylenebis (4-hydroxy-2H-chromen-2-one) as a promising anticancer scaffold with kinesin spindle protein (KSP) inhibitory activity under malignant condition. A series of biscoumarin derivatives (MN1 to MN30) with different substituent were synthesized, and their anticancer activity was explored. Six biscoumarin derivatives that were found active were further selected to formulate organic nanoparticles (ONPs). Anticancer activity of both the forms (viz...
Abstract Xanthine oxidase (XO) is a form of xanthine oxidoreductase, a type of enzyme that plays a key role in the induction of hyperuricemia and raising superoxide radical level in blood. The present study was performed to evaluate the inhibitory activity of isoflavonoids (1-3) isolated from the ethyl acetate fraction of Apios americana, on the catalytic reaction mediated by XO. The isoflavonoids exhibited potential inhibitory activity within microgram/mL along with quenching effect towards XO....
#1De-jiang Kong (SPU: Shenyang Pharmaceutical University)H-Index: 1
#2Ying Wang (SPU: Shenyang Pharmaceutical University)H-Index: 2
Last.Maosheng Cheng (SPU: Shenyang Pharmaceutical University)H-Index: 16
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Abstract Here, we focused on exploring the selectivity mechanism against Nav1.7 over Nav1.4 due to different binding modes of two selected inhibitors. By the superposition of Nav1.7 and Nav1.4 proteins, we selected the most homologous chain of Nav1.7 with Nav1.4, defining the active site of Nav1.4-VSD4 based on the aryl sulfonamide binding site of Nav1.7-VSD4. Comparison of the conformations exhibited by Tyr1386 (Nav1.4) and Tyr1537 (Nav1.7) suggested that the steric hindrance caused by Tyr1386 ...
#1Sameer Hassan (University of Gothenburg)H-Index: 1
#2Johanna Lethin (University of Gothenburg)H-Index: 1
Last.Henrik Aronsson (University of Gothenburg)H-Index: 18
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Abstract Soil salinization is an increasing global threat to economically important agricultural crops such as bread wheat (Triticum aestivum L.). A main regulator of plants’ responses to salt stress is WRKY transcription factors, a protein family that binds to DNA and alters the rate of transcription for specific genes. In this study, we identified 297 WRKY genes in the Chinese Spring wheat genome (Ensembl Plants International Wheat Genome Sequencing Consortium (IWGSC)), of which 126 were ident...
#1Xue-Zhen Liang (SDUTCM: Shandong University of Traditional Chinese Medicine)H-Index: 1
#2Rui LiH-Index: 1
Last.Gang Li (SDUTCM: Shandong University of Traditional Chinese Medicine)
view all 7 authors...
Abstract Zoledronic acid (ZA) is an FDA-approved drug and a third-generation bisphosphonate (BPs). A systematic evaluation of the mechanisms of ZA has not previously been performed. In this study, validated targets of ZA were screened using PubChem, Herbal Ingredients’ Targets Database (HIT), Binding Database (BindingDB), and ChemBank, and potential targets of ZA were identified based on structural characteristics of ligands and proteins. The candidate targets were then assessed using GeneMANIA,...
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