Review paper
Role of HBx in hepatitis B virus persistence and its therapeutic implications
Abstract
Chronic hepatitis B virus infection is a significant risk factor for cirrhosis and hepatocellular carcinoma. The HBx protein is required for virus replication, but the lack of robust infection models has hindered our understanding of HBx functions that could be targeted for antiviral purposes. We briefly review three properties of HBx: its binding to DDB1 and its regulation of cell survival and metabolism, to illustrate how a single viral...
Paper Details
Title
Role of HBx in hepatitis B virus persistence and its therapeutic implications
Published Date
Jun 1, 2018
Journal
Volume
30
Pages
32 - 38
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