Downregulation of Circulating miRs-206-3p and -381-3p May Serve As Putative Serum Biomarkers for Detection of 4,4’-Methylene Diphenyl Diisocyanate Exposure

Occupational exposure to the most widely used diisocyanate, 4,4’-methylene diphenyl diisocyanate (MDI), is a cause of occupational asthma (OA). Early recognition of MDI sensitization and control of MDI exposure is essential for the prevention of MDI-OA, however, there are no accepted immunological tests for identification of MDI-OA. Circulating microRNAs (miRs) have been proposed as biomarkers for asthma, cancers, and other diseases. We...