Dampened STING-Dependent Interferon Activation in Bats
Abstract
Compared with terrestrial mammals, bats have a longer lifespan and greater capacity to co-exist with a variety of viruses. In addition to cytosolic DNA generated by these viral infections, the metabolic demands of flight cause DNA damage and the release of self-DNA into the cytoplasm. However, whether bats have an altered DNA sensing/defense system to balance high cytosolic DNA levels remains an open question. We demonstrate that bats have a...
Paper Details
Title
Dampened STING-Dependent Interferon Activation in Bats
Published Date
Mar 1, 2018
Journal
Volume
23
Issue
3
Pages
297 - 301.e4
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Notes
History