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Cell Host & Microbe
Papers 2078
1 page of 208 pages (2,078 results)
Published in Cell Host & Microbe 15.75
Dominic A. Colosimo1
Estimated H-index: 1
(Rockefeller University),
Jeffrey A Kohn (Rockefeller University)+ -3 AuthorsSean F. Brady36
Estimated H-index: 36
(Rockefeller University)
Summary Despite evidence linking the human microbiome to health and disease, how the microbiota affects human physiology remains largely unknown. Microbiota-encoded metabolites are expected to play an integral role in human health. Therefore, assigning function to these metabolites is critical to understanding these complex interactions and developing microbiota-inspired therapies. Here, we use large-scale functional screening of molecules produced by individual members of a simplified human mic...
Published in Cell Host & Microbe 15.75
Shubhi Pandey2
Estimated H-index: 2
(IITK: Indian Institute of Technology Kanpur),
Jagannath Maharana (IITK: Indian Institute of Technology Kanpur), Arun K. Shukla23
Estimated H-index: 23
(IITK: Indian Institute of Technology Kanpur)
Host-microbiome interactions affect host physiology, but the underlying mechanisms are not well understood. Recent papers from Chen et al. (2019) and Colosimo et al. (2019) in this issue of Cell Host & Microbe demonstrate that metabolites produced by several members of the gut microbiota can efficiently activate host G protein-coupled receptors and influence host physiology.
Published in Cell Host & Microbe 15.75
Jingyan Zhang1
Estimated H-index: 1
(UMMS: University of Massachusetts Medical School),
Xuhang Li (UMMS: University of Massachusetts Medical School)+ -3 AuthorsAlbertha J.M. Walhout43
Estimated H-index: 43
(UMMS: University of Massachusetts Medical School)
Summary Iron is an essential micronutrient for all forms of life; low levels of iron cause human disease, while too much iron is toxic. Low iron levels induce reactive oxygen species (ROS) by disruption of the heme and iron-sulfur cluster-dependent electron transport chain (ETC). To identify bacterial metabolites that affect development, we screened the Keio Escherichia coli collection and uncovered 244 gene deletion mutants that slow Caenorhabditis elegans development. Several of these genes en...
Published in Cell Host & Microbe 15.75
Angela C. Poole12
Estimated H-index: 12
(Cornell University)
Nutrition research is plagued by the reproducibility crisis. Reconciling nutrition studies involving microbiome data presents a modern challenge for researchers. In this issue of Cell Host & Microbe, Bisanz et al., 2019 demonstrate a comprehensive methodology for meta-analysis of microbiome sequence data from high-fat-diet intervention studies.
Published in Cell Host & Microbe 15.75
Leo C. James32
Estimated H-index: 32
(LMB: Laboratory of Molecular Biology),
Till Böcking29
Estimated H-index: 29
(EMBL-EBI: European Bioinformatics Institute)
In this issue of Cell Host & Microbe, Summers et al. (2019) use protein engineering to generate a toolbox of HIV-1 capsid oligomers. In an accompanying Cell Reports paper, Huang et al. (2019) use these oligomers to determine how the capsid engages the kinesin-1 adaptor protein FEZ1.
Published on Jul 1, 2019in Cell Host & Microbe 15.75
Shuo Yang3
Estimated H-index: 3
(CAS: Chinese Academy of Sciences),
Yaya Zhao (CAS: Chinese Academy of Sciences)+ 4 AuthorsLei Pan11
Estimated H-index: 11
(CAS: Chinese Academy of Sciences)
Summary Interorgan immunological communication is critical to connect the local-systemic innate immune response and orchestrate a homeostatic host defense. However, the factors and their roles in this process remain unclear. We find Drosophila IMD response in guts can sequentially trigger a systemic IMD reaction in the fat body. Sugar alcohols of the polyol pathway are essential for the spatiotemporal regulation of gut-fat body immunological communication (GFIC). IMD activation in guts causes el...
Published in Cell Host & Microbe 15.75
Yu Ti Cheng (MSU: Michigan State University), Li Zhang (MSU: Michigan State University), Sheng Yang He28
Estimated H-index: 28
(MSU: Michigan State University)
In the past four decades, tremendous progress has been made in understanding how plants respond to microbial colonization and how microbial pathogens and symbionts reprogram plant cellular processes. In contrast, our knowledge of how environmental conditions impact plant-microbe interactions is less understood at the mechanistic level, as most molecular studies are performed under simple and static laboratory conditions. In this review, we highlight research that begins to shed light on the mech...
Published in Cell Host & Microbe 15.75
Cosmo Z. Buffalo1
Estimated H-index: 1
(California Institute for Quantitative Biosciences),
Christina M. Stürzel11
Estimated H-index: 11
(University of Ulm)
+ -3 AuthorsXuefeng Ren13
Estimated H-index: 13
(California Institute for Quantitative Biosciences)
Summary Tetherin is a host defense factor that physically prevents virion release from the plasma membrane. The Nef accessory protein of simian immunodeficiency virus (SIV) engages the clathrin adaptor AP-2 to downregulate tetherin via its DIWK motif. As human tetherin lacks DIWK, antagonism of tetherin by Nef is a barrier to simian-human transmission of non-human primate lentiviruses. To determine the molecular basis for tetherin counteraction, we reconstituted the AP-2 complex with a simian te...