SLAMF1 is required for TLR4-mediated TRAM-TRIF–dependent signaling in human macrophages
Abstract
Signaling lymphocytic activation molecule family 1 (SLAMF1) is an Ig-like receptor and a costimulatory molecule that initiates signal transduction networks in a variety of immune cells. In this study, we report that SLAMF1 is required for Toll-like receptor 4 (TLR4)-mediated induction of interferon β (IFNβ) and for killing of Gram-negative bacteria by human macrophages. We found that SLAMF1 controls trafficking of the Toll receptor–associated...
Paper Details
Title
SLAMF1 is required for TLR4-mediated TRAM-TRIF–dependent signaling in human macrophages
Published Date
Feb 12, 2018
Journal
Volume
217
Issue
4
Pages
1411 - 1429
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Notes
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