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Terje Espevik
Norwegian University of Science and Technology
269Publications
65H-index
21kCitations
Publications 269
Newest
Published on Jan 1, 2018in Cell 31.40
Anette Christ7
Estimated H-index: 7
(University of Massachusetts Medical School),
Patrick Günther8
Estimated H-index: 8
(University of Bonn)
+ 23 AuthorsKevin Baßler3
Estimated H-index: 3
(University of Bonn)
Summary Long-term epigenetic reprogramming of innate immune cells in response to microbes, also termed "trained immunity," causes prolonged altered cellular functionality to protect from secondary infections. Here, we investigated whether sterile triggers of inflammation induce trained immunity and thereby influence innate immune responses. Western diet (WD) feeding of Ldlr −/− mice induced systemic inflammation, which was undetectable in serum soon after mice were shifted back to a chow diet (C...
56 Citations Source Cite
Published on Apr 2, 2018in Journal of Cell Biology 8.78
Mariya Yurchenko1
Estimated H-index: 1
(Norwegian University of Science and Technology),
Astrid Skjesol9
Estimated H-index: 9
(Norwegian University of Science and Technology)
+ 6 AuthorsTerje Espevik65
Estimated H-index: 65
(Norwegian University of Science and Technology)
Signaling lymphocytic activation molecule family 1 (SLAMF1) is an Ig-like receptor and a costimulatory molecule that initiates signal transduction networks in a variety of immune cells. In this study, we report that SLAMF1 is required for Toll-like receptor 4 (TLR4)-mediated induction of interferon β (IFNβ) and for killing of Gram-negative bacteria by human macrophages. We found that SLAMF1 controls trafficking of the Toll receptor–associated molecule (TRAM) from the endocytic recycling compartm...
1 Citations Source Cite
Published on Jan 1, 2018in Neonatology 2.69
Anub Mathew Thomas1
Estimated H-index: 1
,
Camilla Schjalm3
Estimated H-index: 3
+ 12 AuthorsCorinna Lau5
Estimated H-index: 5
Background: Meconium aspiration syndrome (MAS) is a severe lung condition affecting newborns and it can lead to a systemic inflammatory response. We previously documented complement activation and cytokine release in a piglet MAS model. Additionally, we showed ex vivo that meconium-induced inflammation was dependent on complement and Toll-like receptors. Objectives: To assess the efficacy of the combined inhibition of complement (C5) and CD14 on systemic inflammation induced in a forceful piglet...
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Published on May 1, 2018in Journal of Thrombosis and Haemostasis 4.90
Espen Waage Skjeflo2
Estimated H-index: 2
,
Dorte Christiansen12
Estimated H-index: 12
+ 6 AuthorsTom Eirik Mollnes53
Estimated H-index: 53
There is extensive cross-talk between the complement system, the Toll-like receptors (TLR) and hemostasis. Consumptive coagulopathy is a hallmark of sepsis and often mediated through increased tissue factor (TF) expression. To study the relative roles of complement, TLRs and TF in Staphylococcus aureus (S. aureus)-induced coagulation. Lepirudin-anticoagulated human whole blood was incubated with the three S. aureus strains Cowan, Wood and Newman. C3 was inhibited with compstatin, C5 with eculizu...
2 Citations Source Cite
Published on May 29, 2018in Frontiers in Physiology 3.39
Korbinian Bösl1
Estimated H-index: 1
(Norwegian University of Science and Technology),
Miriam Giambelluca (Norwegian University of Science and Technology)+ 4 AuthorsBjarte Bergstrøm2
Estimated H-index: 2
(Norwegian University of Science and Technology)
Innate immune signaling is essential to mount a fast and specific immune response to pathogens. Monocytes and macrophages are essential cells in the early response in their capacity as ubiquitous phagocytic cells. They phagocytose microorganisms or damaged cells and sense pathogen/damage-associated molecular patterns (PAMPs/DAMPs) through innate receptors such as Toll-like receptors (TLRs). We investigated a phenomenon where co-signaling from TLR2 and TLR8 in human primary monocytes provides a d...
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Published on Nov 1, 2018in International Journal of Cardiology 4.03
Ola Kleveland3
Estimated H-index: 3
(Norwegian University of Science and Technology),
Thor Ueland57
Estimated H-index: 57
+ 15 AuthorsBjørn Bendz15
Estimated H-index: 15
(Oslo University Hospital)
Abstract Aim To evaluate the effect of interleukin-6 inhibition with tocilizumab on the cytokine network in patients with acute non-ST-elevation myocardial infarction (NSTEMI). Methods 117 patients with acute NSTEMI were randomised to an intravenous infusion of 280 mg tocilizumab or placebo prior to coronary angiography. Blood samples were obtained at baseline, at 6 consecutive points in time during hospitalisation, and at follow-up after 3 and 6 months. Cytokines ( n = 27) were analysed with a ...
2 Citations Source Cite
Published on Jan 1, 2018in Frontiers in Immunology 5.51
Hilde L. Orrem2
Estimated H-index: 2
(University of Oslo),
Per H. Nilsson15
Estimated H-index: 15
+ 15 AuthorsBente Halvorsen38
Estimated H-index: 38
Abstract Background. Elevated interleukin-6 (IL-6) and complement activation are associated with detrimental effects of inflammation in coronary artery disease (CAD). The complement anaphylatoxins C5a and C3a interact with their receptors; the highly inflammatory C5aR1, and the C5aR2 and C3aR. We evaluated the effect of the IL-6 receptor (IL-6R)-antagonist tocilizumab on the expression of the anaphylatoxin receptors in whole blood from non-ST-elevation myocardial infarction (NSTEMI) patients. Se...
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Published on Oct 1, 2018in Molecular Immunology 3.19
Erin E. West8
Estimated H-index: 8
(National Institutes of Health),
Simon Freeley6
Estimated H-index: 6
(King's College London)
+ 7 AuthorsClaudia Kemper23
Estimated H-index: 23
(University of Lübeck)
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Published on Nov 28, 2018in PLOS ONE 2.77
Neda Nejati Moharrami1
Estimated H-index: 1
(Norwegian University of Science and Technology),
Erlend Bjørkøy Tande (Norwegian University of Science and Technology)+ 2 AuthorsVictor L. Boyartchuk1
Estimated H-index: 1
(Norwegian University of Science and Technology)
ROR family of nuclear receptor transcription factors forms nodes connecting metabolic and inflammatory signaling pathways. The RORα members of the family have intrinsic transcriptional activity and they are involved in both activation and repression of a wide range of genes. The role of RORα in control of inflammation has been extensively studied using animal models but its function in human cells is not as well understood. To address this shortcoming, we analyzed how RORα is shaping the inflamm...
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