Increments in serum high-density lipoprotein cholesterol over time are not associated with improved outcomes in incident hemodialysis patients

•Increasing serum HDL-C is associated with worse outcomes in hemodialysis patients. •This underlines the shortcomings of serum HDL concentrations in predicting outcomes. •Future studies should address the role of HDL function in addition to its level. Background Elevated serum high-density lipoprotein cholesterol (HDL-C) has not been associated with better cardiovascular (CV) and all-cause mortality in hemodialysis patients. However, the...