Original paper
NK Cell–Specific CDK8 Deletion Enhances Antitumor Responses
Abstract
Cyclin-dependent kinase 8 (CDK8) is a member of the transcription-regulating CDK family. CDK8 activates or represses transcription by associating with the mediator complex or by regulating transcription factors. Oncogenic activity of CDK8 has been demonstrated in several cancer types. Targeting CDK8 represents a potential therapeutic strategy. Because knockdown of CDK8 in a natural killer (NK) cell line enhances cytotoxicity and NK cells provide...
Paper Details
Title
NK Cell–Specific CDK8 Deletion Enhances Antitumor Responses
Published Date
Apr 1, 2018
Journal
Volume
6
Issue
4
Pages
458 - 466
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Notes
History