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Cancer immunology research
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8.62
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Papers 2586
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#1Siqi Chen (NU: Northwestern University)H-Index: 7
#2Imran Akdemir (Bilkent University)
Last. Caglar CekicH-Index: 12
view all 6 authors...
Accumulating evidence suggests that inhibiting adenosine-generating ecto-enzymes (CD39 and CD73) and/or adenosine A2A or A2B receptors (R) stimulates antitumor immunity and limits tumor progression. Although activating A2ARs or A2BRs causes similar immunosuppressive and protumoral functions, few studies have investigated the distinct role of A2BR in cancer. Here, we showed that A2BR expression by hematopoietic cells was primarily responsible for promoting tumor growth. Deletion of A2BR profoundl...
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#1Tat San Lau (CUHK: The Chinese University of Hong Kong)H-Index: 4
#2Loucia Kit-Ying Chan (CUHK: The Chinese University of Hong Kong)H-Index: 9
Last. Joseph Kwong (CUHK: The Chinese University of Hong Kong)H-Index: 22
view all 9 authors...
Emerging evidence shows that the efficacy of chemotherapeutic drugs are reliant on their capability to induce immunogenic cell death (ICD), thus transforming dying tumor cells into antitumor vaccines. We wanted to uncover potential therapeutic strategies that target ovarian cancer by having a better understanding of the standard-of-care chemotherapy treatment. Here, we showed in ovarian cancer that paclitaxel induced ICD-associated DAMPs (i.e. damage-associated molecular patterns, such as CALR e...
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#1Kaustav P. Shah (Vandy: Vanderbilt University)
#2Haocan Song (VUMC: Vanderbilt University Medical Center)
Last. Douglas B. Johnson (Vandy: Vanderbilt University)H-Index: 40
view all 7 authors...
Immune checkpoint inhibitors (ICIs) are now routinely used in multiple cancers but may induce autoimmune-like side effects known as immune-related adverse events (irAEs). Although classical autoimmune diseases have well-known risk factors, including age, gender, and seasonality, the clinical factors that lead to irAEs are not well-defined. To explore these questions, we assessed 455 patients with advanced melanoma treated with ICI at our center and a large pharmacovigilance database (Vigibase). ...
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#1Zongpu Zhang (SDU: Shandong University)H-Index: 3
#2Jianye Xu (SDU: Shandong University)H-Index: 1
Last. Mingyu Qian (SDU: Shandong University)H-Index: 4
view all 16 authors...
Proneural-to-mesenchymal transition (PMT) is a common process in glioblastoma (GBM) progression that leads to increased radiotherapy resistance. However, the mechanism underlying PMT is poorly understood. Here, we found that tumor-associated macrophages (TAMs) triggered PMT in glioma stem cells (GSCs) via small extracellular vesicles (sEVs). sEVs from monocyte-derived macrophages transferred miR-27a-3p, miR-22-3p and miR-221-3p to GSCs, and these microRNAs (miRs) promoted several mesenchymal (ME...
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#1Sarah Abou Alaiwi (Harvard University)H-Index: 1
#2Amin Nassar (Brigham and Women's Hospital)H-Index: 1
Last. Tarek H. Mouhieddine (Harvard University)H-Index: 8
view all 32 authors...
Prior data have variably implicated the inactivation of the mammalian SWItch/Sucrose Non-Fermentable (mSWI/SNF) complex with increased tumor sensitivity to immune checkpoint inhibitors (ICIs). Herein, we examined the association between mSWI/SNF variants and clinical outcomes to ICIs. We correlated somatic loss-of-function (LOF) variants in a pre-defined set of mSWI/SNF genes (ARID1A, ARID1B, SMARCA4, SMARCB1, PBRM1, and ARID2) with clinical outcomes in cancer patients treated with systemic ICIs...
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#1Yuki KagoyaH-Index: 11
#2Tingxi Guo (Princess Margaret Cancer Centre)H-Index: 7
Last. Yukiko Matsunaga (Princess Margaret Cancer Centre)H-Index: 1
view all 13 authors...
Adoptive immunotherapy can induce sustained therapeutic effects in some cancers. Antitumor T cell grafts are often individually prepared in vitro from autologous T cells, which requires an intensive workload and increased costs. The quality of the generated T cells can also be variable, which affects the therapy's antitumor efficacy and toxicity. Standardized production of antitumor T cell grafts from third-party donors will enable widespread use of this modality if allogeneic T cell responses a...
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#1Shouping Xu (HMU: Harbin Medical University)H-Index: 3
#2Qin Wang (HMU: Harbin Medical University)H-Index: 2
Last. Meiying Shen (HMU: Harbin Medical University)H-Index: 1
view all 12 authors...
Long noncoding RNAs (lncRNAs) that are associated with immune checkpoints have not been identified, and the mechanism by which such lncRNAs might regulate the expression of immune checkpoints is unknown in human cancer. Immune checkpoint-associated long noncoding RNAs (ICP-lncRNAs) were identified and validated via a comprehensive bioinformatic analysis of The Cancer Genome Atlas (TCGA) data. These ICP-lncRNAs were involved in key immune response and immune cell receptor signaling pathways. The ...
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#1Marie-Claire Wagle (Genentech)H-Index: 5
#2Joseph Castillo (Genentech)H-Index: 1
Last. Max BylesjoH-Index: 1
view all 18 authors...
Prostate cancer is the second leading cause of cancer-associated death in men. Despite having a relatively lower tumor mutational burden than most tumor types, multiple gene fusions such as TMPRSS2:ERG have been characterized and linked to more aggressive disease. Individual tumor samples have been found to contain multiple fusions and it remains unknown whether these fusions increase tumor immunogenicity. Here, we investigated the role of fusion burden on the prevalence and expression of key mo...
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#1Julia Huetter (Bayer)
#2Uwe Gritzan (Bayer)H-Index: 1
Last. Andrew Pow (Paradigm)
view all 19 authors...
The immunoglobulin-like domain containing receptor 2 (ILDR2), a type I transmembrane protein belonging to the B7 family of immunomodulatory receptors, has been described to induce an immunosuppressive effect on T-cell responses. Besides its expression in several non-lymphoid tissue types, we found that ILDR2 was also expressed in fibroblastic reticular cells (FRC) in the stromal part of the lymph node. These immunoregulatory cells were located in the T-cell zone and were essential for the recrui...
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We conducted a 7-year case–control study of people ≥30 years of age on the prevalence of influenza, gastroenteritis, hepatitis, and pneumonia infections to indirectly examine whether these infections correlated to malignant cancer formation. Data were extracted from a large medical claims database of a Japanese social health insurance system; the case group included 2,354 people with their first cancer diagnosis in the 7th year of this study, and the control group included 48,395 people with no ...
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Top fields of study
Cancer
Immunotherapy
Cancer immunotherapy
Cancer research
Immune system