Mitogenomic differences between the normal and tumor cells of colorectal cancer patients
Abstract
So far, a reliable spectrum of mitochondrial DNA mutations in colorectal cancer cells is still unknown, and neither is their significance in carcinogenesis. Indeed, it remains debatable whether mtDNA mutations are “drivers” or “passengers” of colorectal carcinogenesis. Thus, we analyzed 200 mitogenomes from normal and cancer tissues of 100 colorectal cancer patients. Minority variant mutations were detected at the 1% level. We showed that...
Paper Details
Title
Mitogenomic differences between the normal and tumor cells of colorectal cancer patients
Published Date
Jan 24, 2018
Journal
Volume
39
Issue
5
Pages
691 - 701
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