P21 activated kinase signaling in cancer
Abstract
The p21 Activated Kinases (PAKs) are a family of serine threonine kinases, that consist of 6 members, PAKs 1-6, which are positioned at an intersection of multiple signaling pathways implicated in oncogenesis. The PAKs were originally identified as protein kinases that function downstream of the Ras related Rho GTPases Cdc42 and Rac. PAK1 and PAK4, which belong to Group I and Group II PAKs, respectively, are most often associated with...
Paper Details
Title
P21 activated kinase signaling in cancer
Published Date
Feb 1, 2019
Journal
Volume
54
Pages
40 - 49
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