Review paper
Perspective: APOBEC mutagenesis in drug resistance and immune escape in HIV and cancer evolution
Abstract
The apolipoprotein B mRNA-editing enzyme, catalytic polypeptide-like (APOBEC) mutational signature has only recently been detected in a multitude of cancers through next-generation sequencing. In contrast, APOBEC has been a focus of virology research for over a decade. Many lessons learnt regarding APOBEC within virology are likely to be applicable to cancer. In this review, we explore the parallels between the role of APOBEC enzymes in HIV and...
Paper Details
Title
Perspective: APOBEC mutagenesis in drug resistance and immune escape in HIV and cancer evolution
Published Date
Mar 1, 2018
Journal
Volume
29
Issue
3
Pages
563 - 572
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