Cardiac macrophages promote diastolic dysfunction
Abstract
Macrophages populate the healthy myocardium and, depending on their phenotype, may contribute to tissue homeostasis or disease. Their origin and role in diastolic dysfunction, a hallmark of cardiac aging and heart failure with preserved ejection fraction, remain unclear. Here we show that cardiac macrophages expand in humans and mice with diastolic dysfunction, which in mice was induced by either hypertension or advanced age. A higher murine...
Paper Details
Title
Cardiac macrophages promote diastolic dysfunction
Published Date
Jan 16, 2018
Volume
215
Issue
2
Pages
423 - 440
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