Original paper
Sirtuin 3 silencing improves oxaliplatin efficacy through acetylation of MnSOD in colon cancer
Abstract
Sirtuin 3 (SIRT3) is the major mitochondria deacetylase and regulates ROS levels by targeting several key proteins, such as those involved in mitochondrial function and antioxidant defenses. This way, SIRT3 balances ROS production and scavenging and promotes cell survival. The aim of this study was to analyze the effect of SIRT3 silencing on the antioxidant response in SW620 colon cancer cell line, and whether this intervention could improve...
Paper Details
Title
Sirtuin 3 silencing improves oxaliplatin efficacy through acetylation of MnSOD in colon cancer
Published Date
Mar 6, 2018
Volume
233
Issue
8
Pages
6067 - 6076
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Notes
History