Improved hepatic γ-tocopherol status limits oxidative and inflammatory stress-mediated liver injury in db/db mice with nonalcoholic steatohepatitis

γ-Tocopherol (γ-T) and its physiological metabolite γ-carboxyethyl-hydroxychroman (γ-CEHC) exhibit antioxidant and anti-inflammatory activities. We hypothesized that improved hepatic γ-T status would protect against NASH in leptin-resistant db/db mice. Wild-type mice were fed a diet without γ-T, and db/db mice were fed the same diet supplemented with or without γ-T for 8 wk. Hepatic γ-T and γ-CEHC levels were increased (P < .05) compared with...