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Weight Loss Strategies in the Elderly: A Clinical Conundrum

Published on Jan 1, 2018in Obesity3.969
· DOI :10.1002/oby.21961
Robert H. Coker19
Estimated H-index: 19
,
Robert R. Wolfe119
Estimated H-index: 119
Abstract
  • References (92)
  • Citations (6)
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References92
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90 CitationsSource
#1Dolores Sánchez-Rodríguez (Autonomous University of Barcelona)H-Index: 6
#2Ester MarcoH-Index: 10
Last. Josep M. Muniesa (Autonomous University of Barcelona)H-Index: 11
view all 7 authors...
Summary Backgrounds & aims The European Society of Clinical Nutrition and Metabolism (ESPEN) consensus definition of malnutrition has been applied in hospitalized older diabetics and middle-aged patients, geriatric outpatients, and healthy elderly and young individuals. In a post-acute care setting, our aim was to assess malnutrition (ESPEN definition) and determine its relationship with sarcopenia in older in-patients deconditioned due to an acute process. Methods Eighty-eight in-patients aged ...
29 CitationsSource
#1Stephan C. Bischoff (University of Hohenheim)H-Index: 63
#2Yves BoirieH-Index: 49
Last. Rocco Barazzoni (UniTS: University of Trieste)H-Index: 29
view all 19 authors...
Summary Overnutrition and sedentary lifestyle result in overweight or obesity defined as abnormal or excessive fat accumulation that may impair health. According to the WHO, the worldwide prevalence of obesity nearly doubled between 1980 and 2008. In 2008, over 50% of both men and women in the WHO European Region were overweight, and approximately 23% of women and 20% of men were obese. Comprehensive diagnostic and therapeutic approaches should include nutritional treatment to favor the best met...
49 CitationsSource
#1Ted G. Graber (UTMB: University of Texas Medical Branch)H-Index: 6
#2Michael S. Borack (UTMB: University of Texas Medical Branch)H-Index: 9
Last. Blake B. Rasmussen (UTMB: University of Texas Medical Branch)H-Index: 53
view all 5 authors...
Amino acid availability stimulates protein synthesis via the mTORC1 (mechanistic target of rapamycin complex 1) signaling pathway. In response to an increase in cellular amino acid availability, translocation of cytosolic mTORC1 to the lysosomal surface is required to stimulate mTORC1 kinase activity. However, research elucidating the amino acid responsive mechanisms have thus far only been conducted in in vitro models. Our primary objective was to determine whether an increase in amino acid ava...
4 CitationsSource
Purpose of reviewTo summarize recent relevant studies regarding nutrition during critical illness and provide recommendations for clinical practice.Recent findingsRecently acquired knowledge regarding nutritional status and risk assessment, body composition, gastric residual volume, prokinetics, tub
3 CitationsSource
#1Walid Bouaziz (UDS: University of Strasbourg)H-Index: 5
#2Thomas Vogel (UDS: University of Strasbourg)H-Index: 16
Last. Pierre Olivier Lang (ARU: Anglia Ruskin University)H-Index: 27
view all 6 authors...
Aging is intrinsically associated with a progressive decline in muscle strength and mass, and aerobic capacity. This contributes to reduced mobility and impaired quality of life (QoL) among seniors. Regular physical activity, and more particularly aerobic training (AT), has demonstrated benefits on adults' health. The aim of this review was to assess the current level of evidence regarding the health benefits of AT in the population aged 70 years and over. A comprehensive, systematic database se...
37 CitationsSource
#2Eva Kiesswetter (FAU: University of Erlangen-Nuremberg)H-Index: 7
Last. Cornell C. Sieber (FAU: University of Erlangen-Nuremberg)H-Index: 43
view all 4 authors...
Frailty and sarcopenia are important concepts in the quest to prevent physical dependence, as geriatrics are shifting towards identifications of early stages of disability. Definitions of both sarcopenia and frailty are still developing, and both concepts clearly overlap in their physical aspects. Malnutrition (both undernutrition and obesity) plays a key role in the pathogenesis of frailty and sarcopenia. The quality of the diet along the lifespan has a close relation with the incidence of both...
63 CitationsSource
#1Emanuele Marzetti (UCSC: Catholic University of the Sacred Heart)H-Index: 41
#2Riccardo Calvani (UCSC: Catholic University of the Sacred Heart)H-Index: 26
Last. Francesco Landi (UCSC: Catholic University of the Sacred Heart)H-Index: 66
view all 11 authors...
Sarcopenia, the age-dependent loss of muscle mass and function, is a common condition among older adults, and is associated with several adverse health outcomes. Owing to the impact of sarcopenia on quality of life, disability and mortality, a greater awareness is necessary in order to correctly identify the condition both in community and geriatric settings. Research on sarcopenia prevention and treatment is developing quickly, but many questions are still unanswered. The core of the sarcopenia...
52 CitationsSource
#1Mette Holst (AAU: Aalborg University)H-Index: 13
#2Tina Beermann (AAU: Aalborg University)H-Index: 3
Last. Henrik Hwjgaard Rasmussen (AAU: Aalborg University)H-Index: 28
view all 7 authors...
Abstract Objective Optimizing protein and energy intake by food in nutritional risk patients is difficult. The aim of this study was to improve the ≥75% of energy and protein requirements. We would like to see nurses take on the role of hosting the nutritional-risk patients, including focusing on bringing nutrition to the forefront in the collaboration between nurses and patients. Methods This was an interventional study that included patients admitted to the Departments of Infectious Diseases, ...
3 CitationsSource
#1W. Jack Rejeski (Wake Forest University)H-Index: 58
#2Walter T. AmbrosiusH-Index: 44
Last. Anthony P. Marsh (Wake Forest University)H-Index: 22
view all 5 authors...
16 CitationsSource
Cited By6
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#1Robert H. Coker (UAF: University of Alaska Fairbanks)H-Index: 19
#2Kenneth J. Shin (UAF: University of Alaska Fairbanks)H-Index: 1
Last. Robert R. Wolfe (University of Arkansas for Medical Sciences)H-Index: 119
view all 8 authors...
Summary Background & aims Older individuals are susceptible to the loss of muscle and accumulation of fat. To address this problem, we have compared protein kinetics following consumption of an essential amino acid (EAA)-enriched meal replacement (EMR) to consumption of a high-protein meal replacement beverage (Bariatric Advantage, BA) using stable isotope methodology. Methods Eight older (67 ± 2), obese (35 ± 2 kg/m2) female and male participants completed two studies using a randomized, crosso...
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#1David Scott (Monash University, Clayton campus)H-Index: 86
#2Markus J. Seibel (USYD: University of Sydney)H-Index: 70
Last. Vasant Hirani (USYD: University of Sydney)H-Index: 20
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1 CitationsSource
#1Hadis Sabour (Tehran University of Medical Sciences)H-Index: 8
Obesity is a condition resulting from fat accumulation, which is related to many chronic autoimmune and inflammatory diseases, particularly cardiovascular disorders and type 2 diabetes mellitus. Adipose tissue (AT) is a storage organ, which regulates energy mobilization by circulating lipids according to energy status. In obesity-related inflammation, different immune cells including monocytes, macrophages, natural killer cells, and lymphocytes may infiltrate into the AT, resulting in the secret...
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#1Tamar S. Polonsky (U of C: University of Chicago)H-Index: 18
#2Lu Tian (Stanford University)H-Index: 47
Last. Mary McGrae McDermott (NU: Northwestern University)H-Index: 74
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Background Among people with lower extremity peripheral artery disease, obesity is associated with faster functional decline than normal weight. The association of weight loss with functional decli...
1 CitationsSource
#1A Rossi (University of Verona)H-Index: 43
#2Sofia Rubele (University of Verona)H-Index: 3
Last. Mauro Zamboni (University of Verona)H-Index: 49
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2 CitationsSource
#1Tae Nyun Kim (Inje University)H-Index: 19
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