Grafting of Bioactive Polymers with Various Architectures: A Versatile Tool for Preparing Antibacterial Infection and Biocompatible Surfaces

Published on Jan 5, 2018in ACS Applied Materials & Interfaces8.456
· DOI :10.1021/acsami.7b14283
Hamza Chouirfa4
Estimated H-index: 4
Margaret D. M. Evans19
Estimated H-index: 19
+ 5 AuthorsVéronique Migonney20
Estimated H-index: 20
The aim of this Research Article is to present three different techniques of poly(sodium styrene sulfonate) (polyNaSS) covalent grafting onto titanium (Ti) surfaces and study the influence of their architecture on biological response. Two of them are “grafting from” techniques requiring an activation step either by thermal or UV irradiation. The third method is a “grafting to” technique involving an anchorage molecule onto which polyNaSS synthesized by reversible addition–fragmentation chain transfer (RAFT) polymerization is clicked. The advantage of the “grafting to” technique when compared to the “grafting from” technique is the ability to control the architecture and length of the grafted polymers on the Ti surface and their influence on the biological responses. This investigation compares the effect of the three different grafting processes on the in vitro biological responses of bacteria and osteoblasts. Overall outcomes of this investigation confirmed the significance of the sulfonate functional gr...
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Cited By5
#1Mylan Lam (ISPG: Institut Galilée)
#2Vivien Moris (ISPG: Institut Galilée)
Last. C. Falentin-Daudré (ISPG: Institut Galilée)H-Index: 5
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Abstract Silicone-based materials are largely used in plenty of fields, especially in the biomedical field as implantable devices for surgery purposes. However, due to recent issues, the safety of the material has been reconsidered. In this work, we aim to graft a bioactive polymer on silicone breast implants shell surface to allow better integration of the implant inside the body and also a decrease of the bacterial adhesion. To functionalize silicone material, we develop a simple method to fir...
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Infections resulting from the attachment of bacteria and biofilm formation on the surface of medical implants give rise to a severe problem for medical device safety. Thus, the development of antibacterial materials that integrate bactericidal and antifouling properties is a promising approach to prevent biomaterial-associated infections. In this study, two types of dopamine-modified polymers, dopamine-terminated quaternary ammonium salt polymer (D-PQAs) with various lengths of N-alkyl chain (D-...
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#1Ju Liu (Chongqing University)H-Index: 2
Last. Kaiyong Cai (Chongqing University)H-Index: 39
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The immune response to an orthopedic implant is closely related to the nearby bone metabolism balance. To modify titanium (Ti) substrates and accordingly regulate the balance between osteoclast activation and osteoblast differentiation, a multifunctional peptide OGP-NAC was synthesized via conjugating an osteogenic growth peptide (OGP) with N-acetylcysteine (NAC). Then, the synthesized peptide was employed to functionalize Ti substrates and the response of both osteoblasts and osteoclasts was in...
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#2Luis E. Velázquez Becerra (UNAM: National Autonomous University of Mexico)
Last. Carmen Alvarez-Lorenzo (University of Santiago de Compostela)H-Index: 50
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Abstract Catheter-associated infections still represent a challenging thread because of the likelihood of biofilm formation. The aim of this work was the surface modification of catheters to immobilize lysozyme and acylase under mild conditions while preserving antimicrobial and anti-quorum sensing performances. Glycidyl methacrylate (GMA) was grafted onto poly(vinyl chloride) (PVC) catheters by a pre-irradiation method. The effects of monomer concentration, pre-irradiation dose, reaction time, ...
#1Hamza Chouirfa (ISPG: Institut Galilée)H-Index: 4
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Abstract Implanted biomaterials play a key role in the current success of orthopedic and dental procedures. Pure titanium and its alloys are the most commonly used materials for permanent implants in contact with bone. However, implant-related infections remain among the leading reasons for failure. The most critical pathogenic event in the development of infection on biomaterials is biofilm formation, which starts immediately after bacterial adhesion. In the last decade, numerous studies report...
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