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Margaret D. M. Evans
Commonwealth Scientific and Industrial Research Organisation
AnatomyMaterials scienceCorneaFibronectinBiology
49Publications
19H-index
1,245Citations
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Publications 48
Newest
#1Balasubramanian Subramanian (CSIR: Council of Scientific and Industrial Research)H-Index: 21
#2Thanka Rajan S (CSIR: Council of Scientific and Industrial Research)H-Index: 1
Last. Avi Bendavid (CSIRO: Commonwealth Scientific and Industrial Research Organisation)H-Index: 25
view all 7 authors...
Diamond like carbon (DLC) films were deposited onto Ti6Al4V and Si wafer substrates by RF plasma enhanced chemical vapor deposition. The influence of dopants such as fluorine (F), silicon (Si), and nitrogen (N) on composition, structure, and biocompatibility was investigated. Ion scattering spectroscopy analysis revealed the presence of dopant atoms in the outer-most layers of the films. Raman studies showed that the position of the G-band shifts to higher frequencies with the fluorine and nitro...
1 CitationsSource
The aim of this Research Article is to present three different techniques of poly(sodium styrene sulfonate) (polyNaSS) covalent grafting onto titanium (Ti) surfaces and study the influence of their architecture on biological response. Two of them are “grafting from” techniques requiring an activation step either by thermal or UV irradiation. The third method is a “grafting to” technique involving an anchorage molecule onto which polyNaSS synthesized by reversible addition–fragmentation chain tra...
5 CitationsSource
#1Vijayaganapathy Vaithilingam (CSIRO: Commonwealth Scientific and Industrial Research Organisation)H-Index: 10
#2Margaret D. M. Evans (CSIRO: Commonwealth Scientific and Industrial Research Organisation)H-Index: 19
Last. Bernard E. Tuch (CSIRO: Commonwealth Scientific and Industrial Research Organisation)H-Index: 26
view all 6 authors...
Pericapsular fibrotic overgrowth (PFO) is associated with poor survival of encapsulated islets. A strategy to combat PFO is the use of mesenchymal stem cells (MSC). MSC have anti-inflammatory properties and their potential can be enhanced by stimulation with proinflammatory cytokines. This study investigated whether co-encapsulation or co-transplantation of MSC with encapsulated islets would reduce PFO and improve graft survival. Stimulating MSC with a cytokine cocktail of IFN-γ and TNF-α enhanc...
10 CitationsSource
#1V. V. Anusha Thampi (CSIR: Council of Scientific and Industrial Research)H-Index: 3
#2Avi Bendavid (CSIRO: Commonwealth Scientific and Industrial Research Organisation)H-Index: 25
Last. Balasubramanian Subramanian (CSIR: Council of Scientific and Industrial Research)H-Index: 21
view all 7 authors...
Abstract Surface modifications of metallic implants are important in order to protect the underlying metals from the harsh corrosive environment inside the human body and to minimize the losses caused by wear. Recently, researches are carried out in developing bioactive surfaces on metallic implants, which supports the growth and proliferation of cells on to these surfaces. Titanium silicon nitride (TiSiN) hard nanocomposites thin films were fabricated on Ti alloys (Ti-6Al–4 V) by pulsed direct ...
2 CitationsSource
#1Hamza ChouirfaH-Index: 4
Last. Véronique MigonneyH-Index: 20
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This contribution reports on grafting of bioactive polymers such as poly(sodium styrene sulfonate) (polyNaSS) onto titanium (Ti) surfaces. This grafting process uses a modified dopamine as an anchor molecule to link polyNaSS to the Ti surface. The grafting process combines reversible addition-fragmentation chain transfer polymerization, postpolymerization modification, and thiol-ene chemistry. The first step in the process is to synthetize architecture controlled polyNaSS with a thiol end group....
5 CitationsSource
#1Helena P. Felgueiras (University of Paris)H-Index: 10
#2Adeline Decambron (École nationale vétérinaire d'Alfort)H-Index: 4
Last. Véronique Migonney (University of Paris)H-Index: 20
view all 7 authors...
Abstract Ti6Al4V is commonly used for orthopedic applications. This study was designed to test the potentially added benefit of Ti6Al4V functionalized with a bioactive polymer poly(sodium styrene sulfonate) both in vitro and in vivo . Cell-based assays with MC3T3-E1 osteoblast-like cells were used to measure the cell adhesion strength, cell spreading, focal contact formation, cell differentiation and the mineralization of extracellular matrix on grafted and ungrafted Ti6Al4V discs in combination...
11 CitationsSource
#1Vijayaganapathy Vaithilingam (CSIRO: Commonwealth Scientific and Industrial Research Organisation)H-Index: 10
#2Margaret D. M. Evans (CSIRO: Commonwealth Scientific and Industrial Research Organisation)H-Index: 19
Last. Bernard E. TuchH-Index: 26
view all 5 authors...
Pericapsular fibrotic overgrowth (PFO) is a problem that thwarts full implementation of cellular replacement therapies involving encapsulation in an immunoprotective material, such as for the treatment of diabetes. Mesenchymal stem cells (MSCs) have inherent anti-inflammatory properties. We postulated that coencapsulation of MSCs with the target cells would reduce PFO. A hepatoinsulinoma cell line (HUH7) was used to model human target cells and was coencapsulated with either human or mouse MSCs ...
3 CitationsSource
#1Musarat Ishaq (CSIRO: Commonwealth Scientific and Industrial Research Organisation)H-Index: 8
#2Anthony Rowe (CSIRO: Commonwealth Scientific and Industrial Research Organisation)H-Index: 3
Last. Kostya Ostrikov (CSIRO: Commonwealth Scientific and Industrial Research Organisation)H-Index: 56
view all 6 authors...
Atmospheric-pressure plasmas (APs) have been identified as a promising cancer therapy that is able to preferentially kill neoplastic cells through apoptosis. In vitro studies suggest that AP-generated reactive oxygen species (ROS) are the principal triggers of apoptosis-related signaling cascades via oxidative stress and direct interference with DNA, proteins, and other cellular components. The results of this study corroborate an ROS-mediated mechanism of cancer cell death, with apoptosis in AP...
8 CitationsSource
#1Helena P. Felgueiras (ISPG: Institut Galilée)H-Index: 10
#2Margaret D. M. Evans (CSIRO: Commonwealth Scientific and Industrial Research Organisation)H-Index: 19
Last. Véronique Migonney (ISPG: Institut Galilée)H-Index: 20
view all 3 authors...
Abstract This study is focused on understanding the underlying mechanisms involved in the improved in vitro and in vivo responses of osteoblasts on poly(sodium styrene sulfonate) (poly(NaSS)) functionalized Ti6Al4V surfaces. We probed the contribution of cell-adhesive glycoproteins fibronectin (Fn) and vitronectin (Vn) in the initial adhesion of MC3T3-E1 osteoblastic cells to poly(NaSS) functionalized and control Ti6Al4V surfaces. Firstly, culture media containing serum depleted of Fn and Vn (DD...
15 CitationsSource
#1Gagan Kaur (CSIRO: Commonwealth Scientific and Industrial Research Organisation)H-Index: 5
#2Raju Adhikari (CSIRO: Commonwealth Scientific and Industrial Research Organisation)H-Index: 25
Last. Pathiraja A. Gunatillake (CSIRO: Commonwealth Scientific and Industrial Research Organisation)H-Index: 28
view all 7 authors...
Recently conducting and electroactive polymers have received the attention of researchers to explore their potential in biomedical applications. Polyurethanes (PUs) are of particular interest to make conductive polymer composites by the incorporation of conductive particles because of their inherent biocompatibility, biostability, excellent processability and good mechanical properties. In the present work, conductive composites of graphene and a siloxane polyurethane (Elast-Eon™) were prepared....
22 CitationsSource
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