Tools for protein science

When I started as a Ph.D. student in Australia in 1961, no one in our department, or for that matter in the entire University of Adelaide, had a computer. All of our calculations had to be done by hand. Determining a projection electron density map for a simple small molecule crystal structure, for example, took three days and nights of solid effort. (But as I realized later, it did give one a deep understanding of the nitty-gritty of X-ray...