Effect of hydroxypropyl-β–cyclodextrin on lipid membrane fluidity, stability and freeze-drying of liposomes

Although liposomes loaded with drug-cyclodextrin complexes have been proposed as drug delivery systems, the effects of cyclodextrins on the stability and fluidity of lipid membranes is still poorly understood. In this study, liposomes were prepared with the thin film hydration method and the effects of hydroxypropyl-β-cyclodextrin (HP-β-CD) on dipalmitoyl phosphatidyl choline (DPPC) membranes were investigated for the first time by differential...