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Insulin Access to Skeletal Muscle is Preserved in Obesity Induced by Polyunsaturated Diet

Published on Jan 1, 2018in Obesity3.97
· DOI :10.1002/oby.22057
Josiane L. Broussard7
Estimated H-index: 7
(CU: University of Colorado Boulder),
Josiane L. Broussard6
Estimated H-index: 6
(CU: University of Colorado Boulder)
+ 3 AuthorsCathryn M. Kolka15
Estimated H-index: 15
(Cedars-Sinai Medical Center)
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Abstract
Diets high in saturated fat induce obesity and insulin resistance and impair insulin access to skeletal muscle, leading to reduced insulin levels at the muscle cell surface available to bind insulin receptors and induce glucose uptake. In contrast, diets supplemented with polyunsaturated fat improve insulin sensitivity (SI) and reduce the risk for type 2 diabetes. It was hypothesized that a diet high in polyunsaturated fat would preserve SI and insulin access to muscle, as compared with a diet high in saturated fat.After 12 weeks of control, saturated (LARD), or polyunsaturated (salmon oil [SO]) high-fat diet feeding, muscle SI and insulin access to skeletal muscle were measured by using lymph, a surrogate of skeletal muscle interstitial fluid.Both high-fat diets induced similar weight gain, yet only LARD impaired SI. Hyperinsulinemia in the LARD group did not induce an increase in basal interstitial insulin, suggesting reduced insulin access to muscle after LARD, but not after SO.A diet high in polyunsaturated fat does not impair insulin access to muscle interstitium or induce insulin resistance as observed with a saturated fat diet, despite similar weight gain. Future studies should determine whether dietary SO supplementation improves impairments in insulin access to skeletal muscle.
  • References (31)
  • Citations (1)
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References31
Newest
Published on Sep 1, 2016in Obesity3.97
Josiane L. Broussard7
Estimated H-index: 7
(Cedars-Sinai Medical Center),
Ana Valeria B. Castro10
Estimated H-index: 10
(Cedars-Sinai Medical Center)
+ 6 AuthorsCathryn M. Kolka15
Estimated H-index: 15
(Cedars-Sinai Medical Center)
Objective Insulin must move from the blood to the interstitium to initiate signaling, yet access to the interstitium may be impaired in cases of insulin resistance, such as obesity. This study investigated whether consuming a short- and long-term high-fat diet (HFD) impairs insulin access to skeletal muscle, the major site of insulin-mediated glucose uptake. Methods Male mongrel dogs were divided into three groups consisting of control diet (n = 16), short-term (n = 8), and long-term HFD (n = 8)...
Published on Jan 1, 2016in Diabetologia7.11
Josiane L. Broussard6
Estimated H-index: 6
(Cedars-Sinai Medical Center),
Michael D. Nelson13
Estimated H-index: 13
(Cedars-Sinai Medical Center)
+ 7 AuthorsRichard N. Bergman103
Estimated H-index: 103
(Cedars-Sinai Medical Center)
Aims/hypothesis The worldwide incidence of obesity and diabetes continues to rise at an alarming rate. A major cause of the morbidity and mortality associated with obesity and diabetes is heart disease, yet the mechanisms that lead to cardiovascular complications remain unclear.
Published on Oct 1, 2015in Biogerontology3.81
José Manuel Villaiba35
Estimated H-index: 35
(UCO: University of Córdoba (Spain)),
José A. López-Domínguez7
Estimated H-index: 7
(UCO: University of Córdoba (Spain))
+ 13 AuthorsJulia Ariza5
Estimated H-index: 5
(UCO: University of Córdoba (Spain))
The Membrane Theory of Aging proposes that lifespan is inversely related to the level of unsaturation in membrane phospholipids. Calorie restriction (CR) without malnutrition extends lifespan in many model organisms, which may be related to alterations in membrane phospholipids fatty acids. During the last few years our research focused on studying how altering the predominant fat source affects the outcome of CR in mice. We have established four dietary groups: one control group fed 95 % of a p...
Published on Jul 1, 2015in Cardiovascular Research7.01
Joshua P. Scallan14
Estimated H-index: 14
(MU: University of Missouri),
Michael A. Hill40
Estimated H-index: 40
(MU: University of Missouri),
Michael J. Davis50
Estimated H-index: 50
(MU: University of Missouri)
Aims Lymphatic vessel dysfunction is an emerging component of metabolic diseases and can lead to tissue lipid accumulation, dyslipidaemia, and oedema. While lymph leakage has been implicated in obesity and hypercholesterolaemia, whether similar lymphatic dysfunction exists in diabetes has not been investigated. Methods and results To measure the lymphatic integrity of transgenic mice, we developed a new assay that quantifies the solute permeability of murine collecting lymphatic vessels. Compare...
Published on Jan 1, 2015in Obesity3.97
Ana Valeria B. Castro10
Estimated H-index: 10
(Cedars-Sinai Medical Center),
Orison O. Woolcott9
Estimated H-index: 9
(Cedars-Sinai Medical Center)
+ 16 AuthorsIsaac Asare-Bediako2
Estimated H-index: 2
(Cedars-Sinai Medical Center)
Objectives To determine whether a selective increase of visceral adipose tissue content will result in insulin resistance. Methods Sympathetic denervation of the omental fat was performed under general inhalant anesthesia by injecting 6-hydroxydopamine in the omental fat of lean mongrel dogs (n = 11). In the conscious animal, whole-body insulin sensitivity was assessed by the minimal model (SI) and the euglycemic hyperinsulinemic clamp (SICLAMP). Changes in abdominal fat were monitored by magnet...
Ian R. Lanza24
Estimated H-index: 24
(Mayo Clinic),
Agnieszka U. Blachnio-Zabielska6
Estimated H-index: 6
(Mayo Clinic)
+ 6 AuthorsPiotr Zabielski5
Estimated H-index: 5
(Mayo Clinic)
Omega-3 polyunsaturated fatty acids (n-3 PUFAs) enhance insulin sensitivity and glucose homeostasis in rodent models of insulin resistance. These beneficial effects have been linked with anti-inflammatory properties, but emerging data suggest that the mechanisms may also converge on mitochondria. We evaluated the influence of dietary n-3 PUFAs on mitochondrial physiology and muscle lipid metabolites in the context of high-fat diet (HFD) in mice. Mice were fed control diets (10% fat), HFD (60% fa...
Published on Mar 1, 2013in Reviews in Endocrine & Metabolic Disorders5.52
J. David Symons26
Estimated H-index: 26
(UofU: University of Utah),
E. Dale Abel67
Estimated H-index: 67
(UofU: University of Utah)
Cardiovascular complications are the leading causes of morbidity and mortality in individuals with obesity, type 2 diabetes mellitus (T2DM), and insulin resistance. Complications include pathologies specific to large (atherosclerosis, cardiomyopathy) and small (retinopathy, nephropathy, neuropathy) vessels. Common among all of these pathologies is an altered endothelial cell phenotype i.e., endothelial dysfunction. A crucial aspect of endothelial dysfunction is reduced nitric oxide (NO) bioavail...
Published on Mar 1, 2013in Reviews in Endocrine & Metabolic Disorders5.52
Etto C. Eringa26
Estimated H-index: 26
(VUmc: VU University Medical Center),
Erik H. Serné33
Estimated H-index: 33
(VUmc: VU University Medical Center)
+ 5 Authorsvan Hinsbergh Vw70
Estimated H-index: 70
(VUmc: VU University Medical Center)
Endothelial dysfunction associated with diabetes and cardiovascular disease is characterized by changes in vasoregulation, enhanced generation of reactive oxygen intermediates, inflammatory activation, and altered barrier function. These endothelial alterations contribute to excess cardiovascular disease in diabetes, but may also play a role in the pathogenesis of diabetes, especially type 2. The mechanisms underlying endothelial dysfunction in diabetes differ between type 1 (T1D) and type 2 dia...
Published on Feb 1, 2013in Diabetes, Obesity and Metabolism6.13
Kathryn G. Lamping26
Estimated H-index: 26
(Roy J. and Lucille A. Carver College of Medicine),
Daniel W. Nuno12
Estimated H-index: 12
(Roy J. and Lucille A. Carver College of Medicine)
+ 5 AuthorsMark A. Yorek3
Estimated H-index: 3
(Roy J. and Lucille A. Carver College of Medicine)
Aims The ability of dietary enrichment with monounsaturated (MUFA), n-3, or n-6 polyunsaturated fatty acids (PUFA) to reverse glucose intolerance and vascular dysfunction resulting from excessive dietary saturated fatty acids is not resolved. We hypothesized that partial replacement of dietary saturated fats with n-3 PUFA enriched menhaden oil (MO) would provide greater improvement in glucose tolerance and vascular function compared to n-6 enriched safflower oil (SO) or MUFA-enriched olive oil (...
Jason R. Carter24
Estimated H-index: 24
(MTU: Michigan Technological University),
Christopher E. Schwartz10
Estimated H-index: 10
(MTU: Michigan Technological University)
+ 1 AuthorsMichael Joseph Joyner58
Estimated H-index: 58
The antihypertensive influence of fish oil is controversial, and the mechanisms remain unclear. Because the inverse relation between fish oil and hypertension appears to be partially dependent on the degree of hypertension, we tested the hypothesis that fish oil would elicit more dramatic reductions in mean arterial pressure (MAP) and muscle sympathetic nerve activity (MSNA) in prehypertensive (PHT) compared with normotensive (NT) subjects. Resting MAP, MSNA, and heart rate (HR) were examined be...
Cited By1
Newest
Javier R. Jaldin-Fincati3
Estimated H-index: 3
,
Rafaela V. S. Pereira1
Estimated H-index: 1
+ 1 AuthorsAmira Klip75
Estimated H-index: 75
Whereas the blood microvasculature constitutes a biological barrier to the action of blood-borne insulin on target tissues, the lymphatic microvasculature might act as a barrier to subcutaneously administrated insulin reaching the circulation. Here, we evaluate the interaction of insulin with primary microvascular endothelial cells of lymphatic (HDLEC) and blood (HAMEC) origin, derived from human dermal and adipose tissues, respectively. HDLEC express higher levels of insulin receptor (IR) and s...
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