A Failsafe for Sensing Chromatid Tension in Mitosis with the Histone H3 Tail inSaccharomyces cerevisiae

The yeast protein Shugoshin 1 (Sgo1p) senses tension between sister chromatids during mitotic chromosome alignment. A regulatory region on histone..... Mitotic fidelity is ensured by achieving biorientation on all paired chromosomes. The key signal for proper chromosome alignment is the tension between sister chromatids created by opposing poleward force from the spindles. In the budding yeast, the tension-sensing function requires that the...