GDF15 deficiency exacerbates chronic alcohol- and carbon tetrachloride-induced liver injury
Abstract
Growth differentiation factor 15 (GDF15) has recently been shown to have an important role in the regulation of mitochondrial function and in the pathogenesis of complex human diseases. Nevertheless, the role of GDF15 in alcohol-induced or fibrotic liver diseases has yet to be determined. In this study, we demonstrate that alcohol- or carbon tetrachloride (CCl4)-mediated hepatic GDF15 production ameliorates liver inflammation and fibrosis....
Paper Details
Title
GDF15 deficiency exacerbates chronic alcohol- and carbon tetrachloride-induced liver injury
Published Date
Dec 8, 2017
Journal
Volume
7
Issue
1
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