Original paper
Histone methyltransferase MMSET promotes AID-mediated DNA breaks at the donor switch region during class switch recombination
Abstract
In B cells, Ig class switch recombination (CSR) is initiated by activation-induced cytidine deaminase (AID), the activity of which leads to DNA double-strand breaks (DSBs) within IgH switch (S) regions. Preferential targeting of AID-mediated DSBs to S sequences is critical for allowing diversification of antibody functions, while minimizing potential off-target oncogenic events. Here, we used gene targeted inactivation of histone...
Paper Details
Title
Histone methyltransferase MMSET promotes AID-mediated DNA breaks at the donor switch region during class switch recombination
Published Date
Nov 20, 2017
Volume
114
Issue
49
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Notes
History