Original paper
STIM1 promotes migration, phagosomal maturation and antigen cross-presentation in dendritic cells
Abstract
Antigen cross-presentation by dendritic cells (DC) stimulates cytotoxic T cell activation to promote immunity to intracellular pathogens, viruses and cancer. Phagocytosed antigens generate potent T cell responses, but the signalling and trafficking pathways regulating their cross-presentation are unclear. Here, we show that ablation of the store-operated-Ca2+-entry regulator STIM1 in mouse myeloid cells impairs cross-presentation and DC...
Paper Details
Title
STIM1 promotes migration, phagosomal maturation and antigen cross-presentation in dendritic cells
Published Date
Nov 24, 2017
Journal
Volume
8
Issue
1
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Notes
History