Lamin and the heart
Abstract
Lamins A and C are intermediate filament nuclear envelope proteins encoded by the LMNA gene. Mutations in LMNA cause autosomal dominant severe heart disease, accounting for 10% of dilated cardiomyopathy (DCM). Characterised by progressive conduction system disease, arrhythmia and systolic impairment, lamin A/C heart disease is more malignant than other common DCMs due to high event rates even when the left ventricular impairment is mild. It has...
Paper Details
Title
Lamin and the heart
Published Date
Nov 25, 2017
Journal
Volume
104
Issue
6
Pages
468 - 479
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