Learning health systems, clinical equipoise and the ethics of response adaptive randomisation
Abstract
To give substance to the rhetoric of ‘learning health systems’, a variety of novel trial designs are being explored to more seamlessly integrate research with medical practice, reduce study duration and reduce the number of participants allocated to ineffective interventions. Many of these designs rely on response adaptive randomisation (RAR). However, critics charge that RAR is unethical on the grounds that it violates the principle of...
Paper Details
Title
Learning health systems, clinical equipoise and the ethics of response adaptive randomisation
Published Date
Nov 24, 2017
Journal
Volume
44
Issue
6
Pages
409 - 415
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