Alex John London
Carnegie Mellon University
Publications 85
#1Alex John London (CMU: Carnegie Mellon University)H-Index: 19
One of the fundamental challenges in any field of practical ethics is to articulate a framework for deliberation and decision making that is capable of providing warranted guidance about contentious ethical questions.1 Such a framework has to function effectively in the face of empirical uncertainty and what Rawls refers to as the fact of reasonable pluralism—the fact that individuals often differ in their ideals, ambitions, preferences and conceptions of the good life. One of the perennial ques...
#1Alec Walker (CMU: Carnegie Mellon University)
#2Alex John London (CMU: Carnegie Mellon University)H-Index: 19
International non-governmental organisations (INGO) face a dilemma when deciding whether to intervene in crisis situations where their efforts can be exploited or co-opted by others: intervene and risk becoming complicit with wrongdoing or sit on the sidelines and consign vulnerable people to the ravages of neglect or oppression. In “‘ He who helps the guilty, shares the crime’? INGOs, moral narcissism and complicity in wrongdoing ,” Buth et al argue that concerns about complicity often stifle e...
Dec 27, 2018 in AAAI (National Conference on Artificial Intelligence)
#1Alex John London (CMU: Carnegie Mellon University)H-Index: 19
#2David Danks (CMU: Carnegie Mellon University)H-Index: 14
The widespread deployment and testing of autonomous vehicles in real-world environments raises key questions about how such systems should be regulated. Much of the current debate presupposes that the regulatory system we currently use for regular vehicles is also appropriate for semi- and fully-autonomous ones. In opposition, we first argue that there are serious challenges to regulating autonomous vehicles using current approaches, due to the nature of both autonomous capabilities (and their c...
#1Lauren E. Kelly (UM: University of Manitoba)H-Index: 11
#2Michele P. Dyson (U of A: University of Alberta)H-Index: 5
Last.Xikui Wang (UM: University of Manitoba)H-Index: 1
view all 10 authors...
Although children have historically been excluded from clinical trials (CTs), many require medicines tested and approved in CTs, forcing health care providers to treat their pediatric patients based on extrapolated data. Unfortunately, traditional randomized CTs can be slow and resource-intensive, and they often require multi-center collaboration. However, an adaptive design (AD) framework for CTs could be used to increase the efficiency of pediatric CTs by incorporating prospectively planned mo...
#1Monica Taljaard (Ottawa Hospital Research Institute)H-Index: 33
#2Charles Weijer (UWO: University of Western Ontario)H-Index: 36
Last.David M. Fergusson (Ottawa Hospital Research Institute)H-Index: 126
view all 27 authors...
There is a widely recognized need for more pragmatic trials that evaluate interventions in real-world settings to inform decision-making by patients, providers, and health system leaders. Increasing availability of electronic health records, centralized research ethics review, and novel trial designs, combined with support and resources from governments worldwide for patient-centered research, have created an unprecedented opportunity to advance the conduct of pragmatic trials, which can ultimat...
To give substance to the rhetoric of ‘learning health systems’, a variety of novel trial designs are being explored to more seamlessly integrate research with medical practice, reduce study duration and reduce the number of participants allocated to ineffective interventions. Many of these designs rely on response adaptive randomisation (RAR). However, critics charge that RAR is unethical on the grounds that it violates the principle of equipoise. In this paper, I reconstruct critiques of RAR as...