Original paper
Inflammation-induced IgA+ cells dismantle anti-liver cancer immunity
Abstract
The role of adaptive immunity in early cancer development is controversial. Here we show that chronic inflammation and fibrosis in humans and mice with non-alcoholic fatty liver disease is accompanied by accumulation of liver-resident immunoglobulin-A-producing (IgA+) cells. These cells also express programmed death ligand 1 (PD-L1) and interleukin-10, and directly suppress liver cytotoxic CD8+ T lymphocytes, which prevent emergence of...
Paper Details
Title
Inflammation-induced IgA+ cells dismantle anti-liver cancer immunity
Published Date
Nov 8, 2017
Journal
Volume
551
Issue
7680
Pages
340 - 345
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Notes
History